Alzheimer's disease neuroimaging

Current Opinion in Neurology
Jennifer L Whitwell

Abstract

The aim of this study was to discuss the contribution of neuroimaging studies to our understanding of Alzheimer's disease. We now have the capability of measuring both tau and beta-amyloid (Aβ) proteins in the brain, which together with more traditional neuroimaging modalities, has led the field to focus on using neuroimaging to better characterize disease mechanisms underlying Alzheimer's disease. Studies have utilized tau and Aβ PET, as well as [18F]fluorodeoxyglucose PET, and structural and functional MRI, to investigate the following topics: phenotypic variability in Alzheimer's disease , including how neuroimaging findings are related to clinical phenotype and age; multimodality analyses to investigate the relationships between different neuroimaging modalities and what that teaches us about disease mechanisms; disease staging by assessing neuroimaging changes in the very earliest phases of the disease in cognitively normal individuals and individuals carrying an autosomal dominant Alzheimer's disease mutation; and influence of other comorbidities and proteins to the disease process. The findings shed light on the role of tau and Aβ, as well as age and other comorbidities, in the neurodegenerative process in Alzheimer's di...Continue Reading

References

Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
Dec 10, 2016·Hippocampus·Cassidy M FifordUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 18, 2017·Annals of Clinical and Translational Neurology·Gérard N BischofUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 25, 2017·NeuroImage·Samuel N LockhartWilliam J Jagust
Mar 3, 2017·Annals of Neurology·Bernard J HanseeuwKeith A Johnson
Mar 10, 2017·Scientific Reports·Jong-Yun ParkUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 21, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron P SchultzReisa A Sperling
Mar 24, 2017·Brain : a Journal of Neurology·Duygu TosunUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 11, 2017·Alzheimer Disease and Associated Disorders·Gregory S DayJohn C Morris
May 31, 2017·JAMA Neurology·Jorge SepulcreKeith A Johnson
Jul 25, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kirsi M KinnunenUNKNOWN Dominantly Inherited Alzheimer Network (DIAN)
Jul 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ilya M NasrallahDavid A Wolk
Aug 12, 2017·Journal of Alzheimer's Disease : JAD·Ivan KoychevUNKNOWN Deep and Frequent Phenotyping study team (
Sep 29, 2017·Neurology·Massimo FilippiFederica Agosta
Oct 13, 2017·Annals of Neurology·Prashanthi VemuriClifford R Jack
Oct 21, 2017·Brain : a Journal of Neurology·Michael SchöllOskar Hansson
Oct 21, 2017·Brain : a Journal of Neurology·Joanna Su Xian ChongJuan Zhou
Oct 24, 2017·Journal of Clinical Neurology·Kee Hyung ParkYoung Don Son
Oct 27, 2017·Neurology·Shannon L RisacherUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 6, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David T JonesClifford R Jack
Nov 7, 2017·Human Brain Mapping·Jeffrey S PhillipsMurray Grossman
Nov 22, 2017·NeuroImage. Clinical·Leonardo IaccarinoGil D Rabinovici
Dec 2, 2017·Brain : a Journal of Neurology·Justine MutluGaël Chételat
Dec 9, 2017·Neurobiology of Aging·Cassidy M FifordUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 12, 2017·Brain : a Journal of Neurology·Val J LoweClifford R Jack
Jan 3, 2018·Brain : a Journal of Neurology·Thomas E CopeJames B Rowe
Jan 10, 2018·Brain : a Journal of Neurology·Merle C HoenigAlexander Drzezga
Jan 13, 2018·Annals of Neurology·Jennifer L WhitwellKeith A Josephs
Jan 13, 2018·Neurobiology of Aging·Batool RizviAdam M Brickman
Feb 15, 2018·Journal of Alzheimer's Disease : JAD·Long XieUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 20, 2018·Neurobiology of Aging·Konstantinos PoulakisEric Westman
Mar 9, 2018·Neurobiology of Aging·Sandhitsu R DasUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 15, 2018·Brain : a Journal of Neurology·Clifford R JackRonald C Petersen
Mar 27, 2018·Brain : a Journal of Neurology·Neil P OxtobyDaniel C Alexander
Apr 2, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer L WhitwellKeith A Josephs
Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Katerina A TetzloffJennifer L Whitwell

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