Alzheimer's disease: Only prevention makes sense

European Journal of Clinical Investigation
José Viña, Jorge Sanz-Ros

Abstract

Alzheimer's disease therapeutics is one of the most important endeavours in today's clinical investigation. Over more than 30 years of research, no disease-modifying treatment has been approved by either the FDA or the EMA to treat Alzheimer's disease. Recently, the evidence of pathological alterations in the brain tissue has been gathered showing that the signs of brain damage appear more than 20 years before the onset of Alzheimer's dementia. The major aim of this review is to underpin the idea that in Alzheimer's therapeutics, only prevention makes sense. It is difficult to visualise that would-be patients may be treated with endovenous administration of antibodies for several years to delay the onset of dementia. Rather, changes in lifestyle that should be specific, stratified and personalised are a likely alternative to delay the transition from asymptomatic Alzheimer's to minimal cognitive impairment and from there to dementia. These efforts are of the utmost importance. If we could delay the onset of full-blown dementia by 5 years, the number of demented patients would be almost halved. Thus, emphasis on preventive measures that can be implemented for decades must be supported. This approach, where even mild changes in c...Continue Reading

References

Jul 11, 1996·Nature·M A SmithN Kowall
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M CardosoC R Oliveira
Mar 9, 2005·Annals of the New York Academy of Sciences·Achim Stocker
Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Oct 10, 2007·Archives of Neurology·Greg AllenC Munro Cullum
Aug 12, 2008·The American Journal of Clinical Nutrition·Daniel P Hayes
Dec 17, 2009·JAMA : the Journal of the American Medical Association·Robert C GreenUNKNOWN Tarenflurbil Phase 3 Study Group
Jan 27, 2010·The Mount Sinai Journal of Medicine, New York·Daniel P Perl
Sep 15, 2010·Alzheimer's Research & Therapy·Roy W Jones
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kurt R BrundenJohn Q Trojanowski
Feb 10, 2011·Nature Reviews. Neurology·Christiane ReitzRichard Mayeux
Sep 6, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Constantine G LyketsosDavid S Miller
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Thomas G BeachWalter Kukull
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mathew R BrierBeau M Ances
Aug 10, 2012·The New England Journal of Medicine·Frank M LaFerla
Jan 3, 2013·Annals of Neurology·Prashanthi VemuriClifford R Jack
May 21, 2013·American Journal of Alzheimer's Disease and Other Dementias·Joseph E GauglerKhaled Sarsour
Jul 26, 2013·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Semagacestat Study Group
Jan 2, 2014·JAMA : the Journal of the American Medical Association·Maurice W DyskenPeter D Guarino
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Jan 24, 2014·The New England Journal of Medicine·Stephen SallowayUNKNOWN Bapineuzumab 301 and 302 Clinical Trial Investigators
May 27, 2015·Nature Neuroscience·Karl Herrup
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Vicent Bonet-CostaJose Viña
Nov 1, 2014·Forum for Health Economics & Policy·Julie ZissimopoulosPatricia St Clair
Jun 14, 2016·Aging·Dale E BredesenJamila Ahdidan
Aug 18, 2016·JAMA Neurology·Giuseppe TostoUNKNOWN National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) Fam
Sep 2, 2016·Nature·Jeff SevignyAlfred Sandrock
Apr 7, 2017·Neurology·Norman R RelkinUNKNOWN Alzheimer's Disease Cooperative Study
Dec 10, 2017·Alzheimer's Research & Therapy·Susanne OstrowitzkiUNKNOWN SCarlet RoAD Investigators

❮ Previous
Next ❯

Citations

May 7, 2019·Acta Ophthalmologica·Jacoba A van de KreekePieter Jelle Visser
May 24, 2019·The British Journal of Ophthalmology·Jacoba Alida van de KreekePieter Jelle Visser
May 24, 2019·Journal of Neuroinflammation·Francesco AngelucciJakub Hort
Nov 19, 2019·Frontiers in Aging Neuroscience·Puneet TalwarRachna Agarwal
Oct 20, 2020·Acta Ophthalmologica·Jacoba A van de KreekeFrank D Verbraak
Aug 12, 2020·Journal of Sport and Health Science·Adrian De la RosaMari Carmen Gomez-Cabrera
Jun 1, 2021·Frontiers in Neuroscience·Athanasios LourbopoulosConstantinos Pantos
Dec 8, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V KurmyshevV B Savilov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.