Alzheimer's disease: synaptic dysfunction and Abeta.

Molecular Neurodegeneration
Ganesh M Shankar, Dominic M Walsh

Abstract

Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. Accordingly, it has been proposed that synapse loss underlies the memory impairment evident in the early phase of AD and that since plasticity is important for neuronal viability, persistent disruption of plasticity may account for the frank cell loss typical of later phases of the disease. Extensive multi-disciplinary research has implicated the amyloid beta-protein (Abeta) in the aetiology of AD and here we review the evidence that non-fibrillar soluble forms of Abeta are mediators of synaptic compromise. We also discuss the possible mechanisms of Abeta synaptotoxicity and potential targets for therapeutic intervention.

Associated Clinical Trials

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Nov 1, 1989·Pathology, Research and Practice·C Bertoni-FreddariJ Ulrich
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A RoherD KuKuruga
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y GeinismanF Morrell
Oct 1, 1986·Annals of Neurology·B T HymanA R Damasio
May 1, 1995·Neurobiology of Aging·D W DicksonP Davies
Apr 21, 1995·The Journal of Biological Chemistry·M B PodlisnyD J Selkoe
Nov 1, 1993·Journal of Neurochemistry·C Vigo-PelfreyD B Schenk
Feb 23, 1996·The Journal of Biological Chemistry·Y M KuoA E Roher
Mar 1, 1996·Neuron·D Neveu, R S Zucker
Feb 1, 1997·Chemistry & Biology·J D HarperP T Lansbury
Aug 1, 1997·Journal of Neuropathology and Experimental Neurology·C I SzeL J Martin
Aug 29, 1997·The Journal of Biological Chemistry·D M WalshD B Teplow
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Y HsiaL Mucke
Apr 2, 1999·Scandinavian Journal of Immunology·M NyboE Holm Nielsen
Aug 28, 1999·The Journal of Biological Chemistry·D M WalshD B Teplow
Mar 16, 2001·Trends in Neurosciences·W L KleinC E Finch
Aug 31, 2001·Progress in Neurobiology·N Kemp, Z I Bashir
Oct 31, 2001·Neuron·D J Selkoe
Jun 12, 2002·The Journal of Biological Chemistry·Karie N DahlgrenMary Jo LaDu
Jul 19, 2002·Nature·Hilal A LashuelPeter T Lansbury
Jul 26, 2002·Brain and Cognition·Harry B M Uylings, J M de Brabander
Aug 28, 2002·Biochemical Society Transactions·D M WalshD J Selkoe
Oct 2, 2002·Neuron·Stanislav S ZakharenkoSteven A Siegelbaum
Oct 26, 2002·Science·Dennis J Selkoe

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Citations

Jun 20, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Megan M Varnum, Tsuneya Ikezu
Oct 1, 2011·Experimental Brain Research·Silke BrunholzGerardo Morfini
Jun 4, 2013·Journal of Computational Neuroscience·Kamal AbuhassanLiam Maguire
Sep 21, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Colm Cunningham, Donal Thomas Skelly
Jun 23, 2012·Experimental Neurology·Nicholas M KanaanGerardo A Morfini
Apr 17, 2010·Cell Death and Differentiation·P CalissanoN Canu
Jun 20, 2012·Molecular Neurodegeneration·Yonghao ZhaoYun-wu Zhang
Jan 15, 2011·International Journal of Alzheimer's Disease·Jo V Rushworth, Nigel M Hooper
Jan 23, 2014·Journal of Molecular Cell Biology·Silvia A PurroPatricia C Salinas
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhi-Gang YaoChuan Qin
Mar 26, 2014·Journal of Neurotrauma·Lucia MerloAntonino Germanò
Aug 28, 2010·International Journal of Alzheimer's Disease·Angèle T Parent, Gopal Thinakaran
Feb 22, 2012·Neuromolecular Medicine·Christoffer RosénHenrik Zetterberg
Jan 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Hannah K Wayment-SteeleAngelika Kunze
Nov 5, 2015·Journal of the American Chemical Society·Olga SzczepankiewiczSara Linse
Jul 16, 2013·Redox Report : Communications in Free Radical Research·Greg T SutherlandPaul K Witting
May 23, 2012·Cell Calcium·Tito CalìMarisa Brini
Dec 20, 2014·Molecular Neurodegeneration·Felipe G SerranoNibaldo C Inestrosa
Mar 29, 2016·Neural Plasticity·Sung-Soo Jang, Hee Jung Chung
May 27, 2014·Frontiers in Aging Neuroscience·Bruce X WongJames A Duce
Jun 4, 2015·PloS One·Jenny DworzakPhilip M Murphy
Mar 13, 2014·PloS One·Kristoffer BrännströmAnders Olofsson
Feb 15, 2013·Toxicology and Industrial Health·Mansour A Al-HazmiAyat Os Montasser
Aug 28, 2015·Anais Da Academia Brasileira De Ciências·Michelle L GarcezJosiane Budni
May 13, 2017·Aging Cell·Aleksandra Rozycka, Monika Liguz-Lecznar

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Methods Mentioned

BETA
electron microscopy
AFM
electrophoresis
ELISA
transgenic
electron
atomic force microscopy
light scattering
dot blot

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