Alzheimer's Disease, the "One-Molecule, One-Target" Paradigm, and the Multitarget Directed Ligand Approach

ACS Chemical Neuroscience
María Jesús Oset-Gasque, José Marco-Contelles

Abstract

No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal chemistry, without knowing it, most possibly. The challenge to discover the efficient Multi-Target Small Molecules (MTSMs) for Alzheimer's disease (AD) therapy implies to identify the key combination of biological targets to modulate them, thus including in the design the corresponding pharmacophoric groups able to do it. Universal and polyvalent pharmacophoric groups, able to modulate diverse receptors or enzymatic systems, would simplify the drug discovery process leading to new and more efficient MTSMs for AD.

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Citations

May 29, 2018·CNS Neuroscience & Therapeutics·Eva RamosAlejandro Romero
Nov 30, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Manuela Bartolini, José Marco-Contelles
Feb 5, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Irene Pachón-AngonaLhassane Ismaili
Feb 15, 2019·Future Medicinal Chemistry·Mohamed Benchekroun, Samuele Maramai
Apr 4, 2019·Future Medicinal Chemistry·Filippo BasagniMichela Rosini
Jun 6, 2019·Expert Opinion on Drug Discovery·Juan F GonzálezJose María Sánchez-Montero
Nov 26, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Gaia FancelluM Amélia Santos
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irene Pachòn AngonaLhassane Ismaili
Jun 20, 2020·Medicinal Research Reviews·Claudia AlbertiniMaria L Bolognesi
Jul 12, 2019·Current Vascular Pharmacology·Zhiyong WangHao Li
Jun 4, 2020·International Journal of Molecular Sciences·Óscar M Bautista-AguileraJosé Marco-Contelles
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka Zagórska, Anna Jaromin
Apr 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva RamosJosé Marco-Contelles
Jun 27, 2019·Current Topics in Medicinal Chemistry·Viktoriya IvasivMaria L Bolognesi
Sep 17, 2020·Molecular Neurobiology·Md Sahab UddinMohamed M Abdel-Daim
Jun 10, 2020·Current Topics in Medicinal Chemistry·Valeria V Kleandrova, Alejandro Speck-Planche
Oct 22, 2020·International Journal of Molecular Sciences·Irene Pachón AngonaLhassane Ismaili
Nov 11, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Óscar M Bautista-AguileraMarta Pérez
Jan 10, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Leili Jalili-BalehMehdi Khoobi
Feb 4, 2021·ACS Chemical Neuroscience·Yehong GongQingwen Zhang
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Galina F MakhaevaRudy J Richardson
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia AlbertiniMaria Laura Bolognesi
Apr 15, 2021·ACS Chemical Neuroscience·Lukas GoreckiMaria Laura Bolognesi
Jul 6, 2021·RSC Medicinal Chemistry·Winnie Deuther-ConradJosé Marco-Contelles
Feb 2, 2019·ACS Chemical Neuroscience·José Marco-Contelles
Jan 1, 2020·ACS Omega·Carina LemkeMichael Gütschow
Jul 17, 2020·Journal of Medicinal Chemistry·José Marco-Contelles, Yihua Zhang
Jul 17, 2019·ACS Chemical Neuroscience·Dushyant V PatelMange Ram Yadav
Sep 2, 2020·Journal of Medicinal Chemistry·José Marco-Contelles

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