AMACR expression in colorectal cancer is associated with left-sided tumor localization.

Virchows Archiv : an International Journal of Pathology
Andreas MarxGuido Sauter

Abstract

Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the beta-oxidation of branched-chain fatty acids and fatty acid derivatives. Altered expression levels of AMACR have been described in various cancers including colorectal cancer (CRC). To determine the potential prognostic impact of AMACR expression, we analyzed 1,315 CRC on a tissue microarray (TMA) by immunohistochemistry (IHC). Clinical follow-up data were available from all cancer patients. Positive AMACR staining was observed in 1,074 (81.7%) of the 1,315 cases including 276 cancers with weak (21.0%) and 798 cancers with strong staining (60.7%). AMACR IHC was significantly associated with tumor grade, stage, non-mucinous phenotype, and left-sided tumor localization (p < 0.0001 each). AMACR positivity was observed in 65.8% of cancers from the right-sided colon, in 73.2% of cancers from the colon transversum, in 81.1% of cancers from the colon descendens, and in 88.9% of the distal left-sided cancers (sigma and rectum; p < 0.0001). However, AMACR staining results were unrelated to clinical outcome. It is concluded that AMACR cannot serve as a prognostic marker in CRC. We hypothesize that the association of AMACR expression with tumor localizatio...Continue Reading

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Citations

Jul 12, 2012·Virchows Archiv : an International Journal of Pathology·Alexey AnnenkovYoichi Ajioka
Feb 9, 2013·International Urology and Nephrology·Shailendra Kapoor
May 27, 2010·World Journal of Gastroenterology : WJG·Sotiris LakisVassiliki Kotoula
Sep 9, 2015·Pathology Oncology Research : POR·Nathaniel MellingAndreas H Marx
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Adrian BoxTarek A Bismar
Feb 5, 2009·Virchows Archiv : an International Journal of Pathology·Paolo Verderio, Antonino Carbone
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Dec 16, 2019·International Journal of Colorectal Disease·Andreas H MarxTill S Clauditz
Dec 14, 2016·Journal of Clinical Gastroenterology·Daniel Y WangBenjamin L Musher

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