Amacrine and bipolar inputs to midget and parasol ganglion cells in marmoset retina

Visual Neuroscience
Carla J AbbottUlrike Grünert

Abstract

Retinal ganglion cells receive excitatory synapses from bipolar cells and inhibitory synapses from amacrine cells. Previous studies in primate suggest that the strength of inhibitory amacrine input is greater to cells in peripheral retina than to foveal (central) cells. A comprehensive study of a large number of ganglion cells at different eccentricities, however, is still lacking. Here, we compared the amacrine and bipolar input to midget and parasol ganglion cells in central and peripheral retina of marmosets (Callithrix jacchus). Ganglion cells were labeled by retrograde filling from the lateral geniculate nucleus or by intracellular injection. Presumed amacrine input was identified with antibodies against gephyrin; presumed bipolar input was identified with antibodies against the GluR4 subunit of the AMPA receptor. In vertical sections, about 40% of gephyrin immunoreactive (IR) puncta were colocalized with GABAA receptor subunits, whereas immunoreactivity for gephyrin and GluR4 was found at distinct sets of puncta. The density of gephyrin IR puncta associated with ganglion cell dendrites was comparable for midget and parasol cells at all eccentricities studied (up to 2 mm or about 16 degrees of visual angle for midget cells...Continue Reading

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Citations

May 8, 2014·Visual Neuroscience·Joanna D CrookDennis M Dacey
Jul 2, 2014·Progress in Retinal and Eye Research·Mrinalini HoonRachel O L Wong
Dec 21, 2016·The Journal of Comparative Neurology·Rania A MasriUlrike Grünert
Sep 7, 2017·The Journal of Comparative Neurology·Ashleigh J ChandraUlrike Grünert
Apr 2, 2015·The Journal of Pharmacology and Experimental Therapeutics·Heather D Snell, Eric B Gonzales
Dec 18, 2019·The Journal of Comparative Neurology·Sara S PattersonDavid W Marshak
Apr 13, 2021·The Journal of Comparative Neurology·Andrea S BordtDavid W Marshak
May 23, 2021·Brain Structure & Function·Ulrike GrünertPaul R Martin

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