PMID: 9653525Jul 8, 1998Paper

Amantadine: a potential treatment for the minimally conscious state

Brain Injury : [BI]
R D ZafonteN R Mann

Abstract

Pharmacologic strategies have been advocated to enhance the neurorehabilitation of persons with severe traumatic brain injury. Dopaminergic pathways have been felt to play a significant role in arousal. Employing single case design methodology we present the case of a survivor of severe traumatic brain injury who appeared to have a dose dependent response to the pro-dopaminergic medication amantadine. Further research is necessary to clarify the role of pharmacotherapy in the improvement of functional outcome.

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