Amantadine aerosol in humans.

Antimicrobial Agents and Chemotherapy
V KnightR K Wilson

Abstract

Seven well volunteers and three patients with a naturally occurring influenza A/USSR/77 (H1N1)-like infection were given amantadine by small-particle aerosol with a Collison generator modified for this purpose. Inhalation periods for the volunteers were increased on consecutive weekends from 15 min to 1 h, 4 h, 9 h, and 2 consecutive days of 6 h each. The particle size was 1.2-micrometer mass median diameter, and the concentration of inhaled aerosol ranged from 47 to 75 microgram/liter. Estimates of retained doses in 9 h were 74 to 149 mg. About two-thirds of the dose was recovered in the urine. Pulmonary function studies did not vary significantly from base-line values and were within a normal range for five of seven volunteers. Two volunteers with a moderate reduction in mid-maximal flow before exposure had a total of three episodes of coughing and wheezing associated with moderate reductions in mid-maximal flow values. These episodes cleared spontaneously or improved promptly after isoproterenol therapy. The patients with influenza tolerated the treatment well and recovered promptly.

References

Jul 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·S Z WilsonE W Larson
Feb 1, 1977·Journal of Clinical Microbiology·H W YoungE W Larson
Jun 1, 1976·The Journal of Infectious Diseases·J S WalkerR O Spertzel
Jan 1, 1971·The American Review of Respiratory Disease·J F MorrisL C Johnson

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Citations

Jan 1, 1980·Pharmacology & Therapeutics·J S Oxford, A Galbraith
Oct 31, 1981·Lancet·V KnightR B Couch
Apr 1, 1980·Antimicrobial Agents and Chemotherapy·S Z WilsonR B Couch
Nov 1, 1990·Antimicrobial Agents and Chemotherapy·R L AtmarR B Couch

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