Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model

Cancer Letters
Prosenjit SahaSukta Das

Abstract

Swertia chirata, is a bitter plant, used in the Indian system of medicine (Ayurveda) for various human ailments. Our laboratory was the first to report the chemopreventive effect of this plant. The antiproliferative and pro-apoptotic action of amarogentin rich fraction of S. chirata is now demonstrated on a mouse skin carcinogenesis model. Immunohistochemical localization revealed a reduction in proliferating and increase in apoptotic cells in skin lesion following treatment, also reflected in the expression of molecular markers--Cox-II and caspase-3 proteins. It may be possible to calculate relative risk, relative protection and attributable risk from the action of test agents on proliferation and apoptosis.

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Citations

Jan 23, 2016·Frontiers in Pharmacology·Vijay Kumar, Johannes Van Staden
Jan 14, 2009·Phytotherapy Research : PTR·Satyendra SuryawanshiR C Gupta
Jan 13, 2015·Cell Biochemistry and Biophysics·Hai-Kang HuaXiao-Hong Zhu
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Aug 4, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Ho-Shan NiuJuei-Tang Cheng
May 12, 2017·The American Journal of Chinese Medicine·Jie LiYuan-Zhong Wang
Jul 9, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simon R FosterWalter G Thomas
Sep 14, 2018·Recent Patents on Anti-infective Drug Discovery·Kanika PatelDinesh K Patel

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