Ambiguous effect of signals transmitted by the vagus nerve on fibrosarcoma incidence and survival of tumor-bearing rats

Neuroscience Letters
Lucia MikovaB Mravec

Abstract

While the parasympathetic nervous system appears to be involved in the regulation of tumor progression, its exact role is still unclear. Therefore, using a rat BP6-TU2 fibrosarcoma tumor model, we investigated the effect of (1) reduction of vagal activity produced by subdiaphragmatic vagotomy; and (2) enhancement of vagal activity produced by continuous delivery of electric impulses to the cervical part of the vagus nerve on tumor development and survival of tumor-bearing rats. We also evaluated the expression of cholinergic receptors within in vitro cultivated BP6-TU2 cells. Interestingly, we found that both, vagal stimulation and subdiaphragmatic vagotomy slightly reduced tumor incidence. However, survival of tumor-bearing rats was not affected by any of the experimental approaches. Additionally, we detected mRNA expression of the α1, α2, α5, α7, and α10 subunits of nicotinic receptors and the M1, M3, M4, and M5 subtypes of muscarinic receptors within in vitro cultivated BP6-TU2 cells. Our data indicate that the role of the vagus nerve in modulation of fibrosarcoma development is ambiguous and uncertain and requires further investigation.

References

Mar 21, 1998·BMJ : British Medical Journal·A EkbomO Nyrén
Jul 18, 2001·Brain Research. Molecular Brain Research·J TsengP A Wackym
Dec 20, 2002·Nature·Kevin J Tracey
Mar 12, 2003·Life Sciences·Carol L Williams
Mar 31, 2004·The Lancet Oncology·Frank EntschladenKurt S Zaenker
Apr 7, 2005·The Lancet Oncology·Yori GidronMartin Glennie
Jan 26, 2006·Cancer Immunology, Immunotherapy : CII·Kerstin LangKurt S Zaenker
Dec 13, 2006·Acta Neurologica Scandinavica·David M Labiner, Geoffrey L Ahern
May 4, 2007·The Journal of Clinical Investigation·Wan-Wan Lin, Michael Karin
Apr 7, 2009·Autonomic Neuroscience : Basic & Clinical·Ann PetterssonDick S Delbro
Jul 21, 2009·Immunobiology·Chiara PortaAntonio Sica
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jun 5, 2010·The Lancet Oncology·Katarina Ondicova, Boris Mravec
Aug 3, 2010·Journal of Korean Medical Science·Do Hoon KimYoung Eun Kim
Jul 13, 2013·Science·Claire MagnonPaul S Frenette
Aug 22, 2014·Science Translational Medicine·Chun-Mei ZhaoDuan Chen

❮ Previous
Next ❯

Citations

Aug 10, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Tibensky, B Mravec

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.