Ambivalent effect of immunoglobulins on the complement system: activation versus inhibition

Molecular Immunology
Milan Basta

Abstract

Pathogen and self-specific antibodies are known for their ability to trigger generation of active complement fragments that then serve as effectors of cell damage. The remainder of the immunoglobulin pool of the host has the capacity to quench harmful effects of activated complement cascade by preventing active complement fragments from binding to their specific receptors. This scavenging function is mediated by different acceptor sites within the immunoglobulin molecule. Large fragments, such as C3b and C4b are preferentially bound to the Fc region, while biologically potent C3a and C5a anaphylatoxins get neutralized by low-affinity interaction with the constant domain of the F(ab)(2.) The ambivalent effect of immunoglobulins on the complement system implies their role in homeostasis as well as expansion of use of high-dose intravenous immunoglobulins in diseases and states mediated by inappropriate complement activation.

Associated Clinical Trials

References

Apr 21, 1988·Nature·A R Duncan, G Winter
Dec 10, 1987·The New England Journal of Medicine·Y Matzner
Feb 1, 1995·Current Opinion in Immunology·V D Miletic, M M Frank
Jun 16, 2005·The Journal of Biological Chemistry·James N ArnoldRobert B Sim
Jul 4, 2006·Immunology Letters·James N ArnoldRobert B Sim
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thiruma V ArumugamMark P Mattson

❮ Previous
Next ❯

Citations

Jan 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stanley C JordanAshley A Vo
Aug 14, 2012·Current Infectious Disease Reports·Susanne Toussaint, Herwig Gerlach
Dec 5, 2009·Nature Reviews. Drug Discovery·Eric Wagner, Michael M Frank
Nov 23, 2012·The New England Journal of Medicine·Erwin W Gelfand
Jul 9, 2009·Transplantation·Stanley C JordanAshley A Vo
Apr 12, 2014·Fibrogenesis & Tissue Repair·Nicole L RosinJean-Francois Légaré
Jul 6, 2014·Experimental & Translational Stroke Medicine·Alexander WidiapradjaThiruma V Arumugam
Dec 4, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ányelo DuranJosé L Castillo
Jan 31, 2012·Medicina clínica·Rocío Ramos-MedinaSilvia Sánchez-Ramón
Dec 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ruth F Padmore
May 23, 2015·Acta Neurologica Scandinavica·S Živković
Mar 10, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Theo RispensRob C Aalberse
Feb 9, 2016·Expert Review of Clinical Immunology·Federica PulvirentiIsabella Quinti
Jun 26, 2009·Trends in Pharmacological Sciences·Royston Jefferis
May 16, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C GaleottiS-V Kaveri
Oct 22, 2009·Clinical and Experimental Immunology·E Fernández-CruzS Sánchez Ramón
Nov 4, 2009·Clinical and Experimental Immunology·A DurandyR Rieben
Aug 1, 2015·Annals of Intensive Care·Perihan Ergin OzcanFigen Esen
Jun 12, 2012·MAbs·Frédéric Ducancel, Bruno H Muller
Jun 30, 2012·Autoimmunity Reviews·Olga L QuinteroJuan-Manuel Anaya
Jan 30, 2015·Frontiers in Immunology·Andrea MatucciAlessandra Vultaggio
May 4, 2016·Immunotherapy·Angel L CorbíAngeles Domínguez-Soto
Jul 8, 2016·Annals of Clinical and Translational Neurology·Faith H BrennanMarc J Ruitenberg
Jan 18, 2017·Expert Review of Neurotherapeutics·Kjara S PilchBenjamin R Wakerley
Dec 13, 2017·Reviews in the Neurosciences·Figen EsenM Dustin Boone
Jan 21, 2017·F1000Research·Herwig Gerlach
May 21, 2011·Expert Review of Clinical Immunology·Stanley C JordanAshley A Vo
Jul 24, 2013·Current Opinion in Allergy and Clinical Immunology·Valérie Gouilleux-GruartAlain Fischer
May 6, 2010·Expert Review of Clinical Immunology·Anne BaerenwaldtFalk Nimmerjahn
Dec 22, 2017·Annals of the New York Academy of Sciences·James F Howard
Dec 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahalakshmi RamadassRichard R Kew
Feb 1, 2020·Journal of Neurotrauma·Min ChenDavid C Reutens
Aug 3, 2021·Frontiers in Immunology·Andrea FariniYvan Torrente

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.