Amblyopia, Strabismus and Refractive Errors in Congenital Ptosis: a systematic review and meta-analysis

Scientific Reports
Yijie WangJuan Ye

Abstract

Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus and refractive errors in congenital ptosis. Cochrane, Pubmed, Medline, Embase, and Web of Science were searched by July 2017. We used random/fixed effects models based on a proportion approach to estimate the prevalence. Heterogeneity would be considered signifcant if the p values less than 0.1 and/or I2 greater than 50%. Subgroup analyses, meta-regression analyses and sensitivity analyses were utilized to explore the potential sources of it. A total of 24 studies selected from 3,633 references were included. The highest prevalence was revealed for myopia with 30.2% (95%CI 3.0-69.8%), followed by 22.7% (95%CI 18.5-27.8%) for amblyopia, 22.2% (95%CI 7.8-63.1%) for astigmatism, 19.6% (95%CI 16.5-23.2%) for strabismus, 17.3% (95% CI 13.1-22.9%) for anisometropia and 4.0% for hyperopia (95%CI 1.8-7.1%). Significant heterogeneity was identified across most estimates. Our findings suggest that amblyopia, strabismus and r...Continue Reading

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Citations

Feb 28, 2019·Journal of Binocular Vision and Ocular Motility·Anna SchweigertAndrew Harrison
Mar 24, 2020·Journal of Pediatric Ophthalmology and Strabismus·Ozlem UralUgur Erdener
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Apr 12, 2021·Microvascular Research·Zhang XiuyanBi Hongsheng
Sep 21, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Naser OwjiMojtaba Heydari
Dec 30, 2021·International Ophthalmology Clinics·Daniel L JonesKarina Richani

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