Amblyopic deficits in the timing and strength of visual cortical responses to faces

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Éva M BankóZoltán Vidnyánszky

Abstract

Behavioral research revealed that object vision is impaired in amblyopia. Nevertheless, neurophysiological research in humans has focused on the amblyopic effects at the earliest stage of visual cortical processing, leaving the question of later, object-specific neural processing deficits unexplored. By measuring event-related potentials (ERPs) to foveal face stimuli we characterized the amblyopic effects on the N170 component, reflecting higher-level structural face processing. Single trial analysis revealed that latencies of the ERP components increased and were more variable in the amblyopic eye compared to the fellow eye both in strabismic and anisometropic patent groups. Moreover, there was an additional delay of N170 relative to the early P1 component over the right hemisphere, which was absent in the fellow eye, suggesting a slower evolution of face specific cortical responses in amblyopia. On the other hand, distribution of single trial N170 peak amplitudes differed between the amblyopic and fellow eye only in the strabismic but not in the anisometropic patients. Furthermore, the amblyopic N170 latency increment but not the amplitude reduction correlated with the interocular differences in visual acuity and fixation sta...Continue Reading

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Citations

Jul 3, 2013·PloS One·Éva M BankóZoltán Vidnyánszky
Dec 23, 2014·Vision Research·John P KellyAvery H Weiss
Feb 5, 2013·Vision Research·Zaira CattaneoClaus-Christian Carbon
Aug 26, 2014·Frontiers in Integrative Neuroscience·Olivier Joly, Edit Frankó
Jul 6, 2014·Frontiers in Psychology·Lisa M HammBenjamin Thompson

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