Ambra1 modulates the sensitivity of breast cancer cells to epirubicin by regulating autophagy via ATG12

Cancer Science
Wei-Liang SunZheng-Wen Cai

Abstract

The sensitivity of breast cancer cells to epirubicin (EPI) is closely related to the efficacy of the drug and the prognosis of patients. A growing body of research has suggested that autophagy is involved in the treatment of a variety of cancers, including breast cancer, and modifies the sensitivity of anticancer drugs. However, the mechanism by which autophagy participates in cancer therapy and modulates drug sensitivity has not been fully elucidated. In this study, we showed that the expression of Autophagy/Beclin 1 regulator 1 (Ambra1), a key protein of autophagy, was negatively correlated with EPI sensitivity in breast cancer cells. In addition, it altered the sensitivity of breast cancer cells to EPI by regulating EPI-induced autophagy. As a potential mechanism, we demonstrated that autophagy-related protein 12 (ATG12) was a downstream protein that Ambra1-regulated EPI-induced autophagy. Therefore, Ambra1 plays an important role in regulating the sensitivity of breast cancer cells to EPI. And the regulatory effect of Ambra1 on EPI sensitivity is achieved through the regulation of autophagy by targeting ATG12. Overall, we propose a novel mechanism by which autophagy modulates the sensitivity of breast cancer cells to EPI. A...Continue Reading

References

Sep 5, 2002·Biochemical and Biophysical Research Communications·Isei TanidaEiki Kominami
Sep 9, 2005·Nature Reviews. Cancer·Yasuko KondoSeiji Kondo
Jun 21, 2007·The Journal of Biological Chemistry·Serhiy PankivTerje Johansen
Jun 26, 2007·Nature·Gian Maria FimiaFrancesco Cecconi
Aug 23, 2007·Nature Reviews. Molecular Cell Biology·Daniel J Klionsky
Oct 17, 2012·Oncogene·G M FimiaM Piacentini
Dec 4, 2012·Nature Structural & Molecular Biology·Chinatsu OtomoTakanori Otomo
Jul 3, 2013·Seminars in Cancer Biology·Séverine LorinPatrice Codogno
Mar 10, 2015·Annual Review of Biophysics·Nobuo N Noda, Fuyuhiko Inagaki
Jun 3, 2015·Journal of Cell Science·Valentina CianfanelliFrancesco Cecconi
Apr 22, 2016·Clinical and Experimental Pharmacology & Physiology·Shu-Ting PanShu-Feng Zhou
Jan 1, 2015·Molecular & Cellular Oncology·Valentina CianfanelliFrancesco Cecconi
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 31, 2017·Microbial Cell·Zhangyuan YinDaniel J Klionsky
Aug 29, 2017·International Journal of Molecular Sciences·Saori R Yoshii, Noboru Mizushima

❮ Previous
Next ❯

Citations

Jan 29, 2020·Journal of Cellular and Molecular Medicine·Jun MaMingyi Shang
Sep 8, 2020·Journal of Zhejiang University. Science. B·Nan WenZheng-Gui Du
Feb 14, 2020·International Journal of Molecular Sciences·Pauline J Beckmann, David A Largaespada
May 22, 2019·Seminars in Cell & Developmental Biology·Tânia CapelôaPierre Sonveaux
May 4, 2020·The American Journal of the Medical Sciences·Yanli NieFuxiang Zhou
Apr 29, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aurelian Udristioiu, Delia Nica-Badea

❮ Previous
Next ❯

Methods Mentioned

BETA
lipidation
Assay
transfection
xenograft

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.