Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity

Antimicrobial Agents and Chemotherapy
Seong Won ChoiVojo Deretic

Abstract

Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy in vitro and in vivo and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.

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Citations

Feb 6, 2019·Expert Opinion on Drug Metabolism & Toxicology·Vojo Deretic, Graham S Timmins
Oct 17, 2018·Virulence·Seungwha PaikEun-Kyeong Jo
Jun 15, 2019·Expert Opinion on Drug Discovery·Uday S GanapathyThomas Dick
Oct 13, 2020·International Journal of Antimicrobial Agents·Myasar Alkotaji
Dec 10, 2020·Tuberculosis Research and Treatment·Steven C Mitini-NkhomaSisira L Pathirana
Feb 26, 2021·Frontiers in Cellular and Infection Microbiology·Retsepile E MaphasaAdmire Dube
Apr 9, 2021·Frontiers in Cellular and Infection Microbiology·Prashanta SilwalEun-Kyeong Jo
Jun 12, 2021·Frontiers in Immunology·Tamiris Lameira BittencourtRoberta Olmo Pinheiro
Jul 13, 2021·Frontiers in Immunology·Steven C Mitini-NkhomaHenry C Mwandumba
Dec 18, 2020·ACS Pharmacology & Translational Science·Giovanni BocciTudor I Oprea

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