Ambroxol Treatment Suppresses the Proliferation of Chlamydia pneumoniae in Murine Lungs.

Dávid KókaiKatalin Burián


Ambroxol (Ax) is used as a mucolytics in the treatment of respiratory tract infections. Ax, at a general dose for humans, does not alter Chlamydia pneumoniae growth in mice. Therefore, we aimed to investigate the potential anti-chlamydial effect of Ax at a concentration four timed higher than that used in human medicine. Mice were infected with C. pneumoniae and 5-mg/kg Ax was administered orally. The number of recoverable C. pneumoniae inclusion-forming units (IFUs) in Ax-treated mice was significantly lower than that in untreated mice. mRNA expression levels of several cytokines, including interleukin 12 (IL-12), IL-23, IL-17F, interferon gamma (IFN-γ), and surfactant protein (SP)-A, increased in infected mice treated with Ax. The IFN-γ protein expression levels were also significantly higher in infected and Ax-treated mice. Furthermore, the in vitro results suggested that the ERK 1/2 activity was decreased, which is essential for the C. pneumoniae replication. SP-A and SP-D treatments significantly decreased the number of viable C. pneumoniae IFUs and significantly increased the attachment of C. pneumoniae to macrophage cells. Based on our results, a dose of 5 mg/kg of Ax exhibited an anti-chlamydial effect in mice, probably...Continue Reading


Jan 1, 1987·Respiration; International Review of Thoracic Diseases·J Germouty, J L Jirou-Najou
Dec 22, 2000·Respiration; International Review of Thoracic Diseases·M AiharaM Mori
Apr 13, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rebecca E OberleyJeanne M Snyder
Dec 1, 2004·The Biochemical Journal·Claire E McCoyJ Simon C Arthur
Feb 8, 2005·Toxicology and Applied Pharmacology·Carola SeifartHeinz Fehrenbach
Dec 22, 2005·Infection and Immunity·Christine RoshickGrant McClarty
Sep 20, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F PetrovayI Valyi-Nagy
Mar 14, 2009·FEMS Immunology and Medical Microbiology·Manu Sharma, Thomas Rudel
Nov 9, 2010·International Journal of Medical Microbiology : IJMM·Emese P BaloghKatalin Burián
Feb 7, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tímea MosolygóKatalin Burián
May 28, 2013·Apoptosis : an International Journal on Programmed Cell Death·Du KunLi Qi
Jul 17, 2013·Archives of Pharmacal Research·Mutsuo YamayaRyoichi Nagatomi
Aug 24, 2013·Cancer Research·Romain LaraOlivier E Pardo
Nov 21, 2013·Pulmonary Pharmacology & Therapeutics·M CataldiO Piazza
Feb 28, 2014·Brain : a Journal of Neurology·Alisdair McNeillAnthony H V Schapira
Mar 7, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Irena Choroszy-KrólAgnieszka Jama-Kmiecik
Oct 2, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yunhui ZhangZhengli Wang
Aug 16, 2016·Journal of Molecular and Cellular Cardiology·Renáta GáspárTamás Csont
Apr 26, 2017·Frontiers in Cellular and Infection Microbiology·Xiuyun LiShujuan Sun
May 27, 2017·The FEBS Journal·Simon J CookMatthew J Sale
Feb 6, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Roberta Balestrino, Anthony H V Schapira
Oct 20, 2018·Canadian Journal of Microbiology·Junji MatsuoHiroyuki Yamaguchi
Oct 30, 2018·Expert Opinion on Drug Safety·Dorotheea CazanStephan Kölsch
Feb 6, 2019·Expert Opinion on Drug Metabolism & Toxicology·Vojo Deretic, Graham S Timmins
Jun 30, 2019·Frontiers in Cellular and Infection Microbiology·Dezső P VirokKatalin Burián
Oct 13, 2019·Nature Communications·Jan N GalleJohannes H Hegemann
May 30, 2020·International Journal of Molecular Sciences·Márton R SzabóTamás Csont
Aug 21, 2020·BioRxiv : the Preprint Server for Biology·Steven B BradfuteVojo Deretic
Oct 13, 2020·International Journal of Antimicrobial Agents·Myasar Alkotaji

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Phytotherapy Research : PTR
Thomas Brendler, Elizabeth Mary Williamson
The American Journal of Nursing
M B Mallison
Critical Reviews in Food Science and Nutrition
Clemens DöringThomas Becker
Carbohydrate Polymers
Mihiri MendisSenay Simsek
© 2021 Meta ULC. All rights reserved