Ambulatory arterial stiffness index as a predictor of blood pressure response to renal denervation

Journal of Hypertension
Yusuke SataMarkus P Schlaich

Abstract

Renal denervation (RDN) can reduce blood pressure (BP) in patients with resistant hypertension, but less so in patients with isolated systolic hypertension. A possible explanation is that patients with stiffer arteries may have lesser neural contribution to their hypertension. We hypothesized that arterial stiffness predicts the response to RDN. From ambulatory BP monitoring (ABPM), ambulatory arterial stiffness index (AASI) was calculated as 1 - the regression slope of DBP versus SBP. In 111 patients with resistant hypertension, RDN reduced office and 24-h SBP after 3, 6, and 12 months (by -11 ± 22, -11 ± 25, -14 ± 21 mmHg for office, and -4 ± 11, -5 ± 12, -5 ± 15 mmHg for 24-h SBP, respectively, P < 0.01). Patients with baseline AASI above the median (>0.51) showed no change in 24-h SBP at 6 months after RDN (-0.4 ± 12.3 mmHg, P > 0.05), whereas an AASI below 0.51was associated with a marked reduction (-9.3 ± 11.0 mmHg, P < 0.01). Across AASI quartiles, patients in the highest quartile (AASI ≥ 0.60) had lower muscle sympathetic nerve activity than the other three quartiles (39 ± 13 versus 49 ± 13 bursts/min, P = 0.035). The responder rate, defined as a 24-h SBP reduction of at least 5% was 58% in the lowest AASI quartile (<0....Continue Reading

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Citations

May 31, 2018·Journal of Hypertension·Thomas OkonPhilipp Lurz
May 31, 2018·Journal of Hypertension·Yusuke SataMarkus P Schlaich
Feb 5, 2019·Cardiovascular Research·Maria T K ZaldiviaKarlheinz Peter
Apr 14, 2018·Frontiers in Medicine·Yusuke SataMarkus P Schlaich
Sep 12, 2018·Current Hypertension Reports·Raymond R Townsend, Paul A Sobotka
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A K MiroslawskaT K Steigen
Jun 25, 2021·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·A G ChepurnoĭD A Maksimkin
Jul 21, 2021·Journal of Cardiovascular Translational Research·Hao ZhouYuehui Yin

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