Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein beta3-subunit polymorphism C825T in White Europeans

Journal of Human Hypertension
A OlszaneckaEuropean Project on Genes in Hypertension (EPOGH) Investigators

Abstract

The 825T allele of the G-protein beta(3)-subunit is associated with increased intracellular signalling. Its association with hypertension is inconsistent. We, therefore, studied the C825T polymorphism in relation to ambulatory blood pressure as well as left ventricular structure and function in two European populations. We genotyped 248 parents and 318 offspring, enrolled in the European Project on Genes in Hypertension in Cracow, Poland (n=286) and in Novosibirsk, Russian Federation (n=280). The 24-h ambulatory blood pressure was recorded using oscillometric SpaceLabs 90207 monitors. Within each centre, a single observer performed two-dimensionally guided M-mode echocardiography and Doppler sonography to measure left ventricular structure (American Society of Echocardiography conventions) and diastolic function: early (E) and late (A) peak diastolic inflow velocities. We used analysis of covariance and generalized estimating equations to allow for covariables and nonindependence among related subjects. Genotype frequencies were similar (P=0.25) in Cracow and Novosibirsk and amounted to 44.7% for CC, 47.2% for CT, and 8.1% for TT. Among parents (mean age: 51.3 years)-but not among offspring (mean age 25.1 years)-24-h, daytime a...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M A LevineT G Ahn
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Sep 6, 1986·British Medical Journal·J C PetrieM de Swiet
Jan 1, 1984·The American Journal of Cardiology·I InouyeJ Tubau
Aug 1, 1995·The Journal of Clinical Investigation·W SiffertK H Jakobs
Jun 1, 1993·Circulation·W H Barry, J H Bridge
Dec 1, 1996·Circulation Research·K L Koss, E G Kranias
Jan 13, 1998·Nature Genetics·W SiffertB Horsthemke
Apr 1, 1999·The New England Journal of Medicine·Z FarfelT Iiri
Nov 26, 1999·Circulation Research·R P XiaoE G Lakatta
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·W Siffert
Jan 1, 1994·European Journal of Health Law·Johan Legemaate
Feb 12, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Miguel A QuiñonesUNKNOWN Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography
Aug 29, 2002·Blood Pressure Monitoring·Tatiana KuznetsovaEoin O'Brien

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Citations

Jul 14, 2009·Journal of Hypertension·Donna K ArnettUlrich Broeckel
Nov 20, 2013·Neurology Research International·Edoardo CasigliaPatrizia Bisiacchi
Apr 24, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Andrea SempliciniGiulio Ceolotto
May 13, 2009·Molecular and Cellular Endocrinology·Felix Grün, Bruce Blumberg
Apr 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Henry VölzkeHans-Werner Hense
May 24, 2003·Journal of Human Hypertension·M TomaszewskiA F Dominiczak

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