Abstract
Hypertension (HT) accounts for nearly 60% to 80% of renal transplant patients (RT). It is one of the most important risk factors for cardiovascular diseases and may cause chronic graft dysfunction. Therefore, it is important to accurately detect and treat HT. We aimed to evaluate the changes in ambulatory blood pressure monitoring (ABPM) parameters among hypertensive RT after active treatment compared with baseline values. Thirty seven RT (25 men, 12 women, aged 49.4 +/- 11.2 year) diagnosed with mild to moderate HT underwent 24-hour ABPM after a 4-week washout period (W0). For the 23 RT with confirmed HT of a second 24-hour ABPM was recorded after 4 weeks of treatment with doxazosin GITS (-4 mg once daily in the morning), a new formulation of an alpha1-receptor inhibitor (W4). Nondippers were considered when mean blood pressure (BP) showed a < or = 10% reduction during sleep. Statistical analyses included Saphiro-Wilks test, Student t test, and ANOVA. After active treatment systolic, diastolic, and mean BP (SBP, DBP, MBP) significantly decreased during diurnal and 24 hours but not the nocturnal period. No significant change was observed for heart rate nor for pulse pressure during any period. The prevalence dippers increased f...Continue Reading
References
Apr 30, 1992·The American Journal of Cardiology·W B White
Aug 1, 1991·Journal of the American Society of Nephrology : JASN·R G Luke
Jan 1, 1991·American Journal of Hypertension·F PortaluppiM Capanna
Jan 1, 1991·Nephron·P BaumgartK H Rahn
Jul 1, 1983·Journal of Cardiovascular Pharmacology·B A GouldE B Raftery
May 1, 1983·Archives of Internal Medicine·J I DrayerD D Brewer
Feb 1, 1995·Drugs·B FultonE M Sorkin
Apr 1, 1993·Journal of Hypertension·G W LipkinA E Raine
Aug 1, 1996·Hypertension·M A van den DorpelM A Schalekamp
Feb 1, 1997·Transplantation Proceedings·K BuddeH H Neumayer
Nov 25, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G A Mansoor, W B White
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C K FarmerP Sharpstone
Mar 21, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·J RadermacherR Brunkhorst
Jun 2, 1998·American Journal of Hypertension·A CalzolariB Alpert
Oct 8, 1998·Contributions to Nephrology·M ZeierE Ritz
Nov 10, 1998·Nephron·M ZeierE Ritz
Dec 5, 1998·Kidney International. Supplement·A Martínez-CastelaoJ M Grinyó
Jun 29, 1999·Journal of Autonomic Pharmacology·U GerhardtH Hohage
May 23, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F Fernández-VegaJ Alvarez
Jun 9, 2001·Transplantation·D O McGregorK L Lynn
Citations
Jan 8, 2008·Current Hypertension Reports·Daniel J Salzberg
Sep 20, 2011·Journal of the American Society of Hypertension : JASH·Matthew R Weir, Daniel J Salzberg
Oct 26, 2010·Transplantation Proceedings·S BeltránL Pallardó
Dec 17, 2009·Transplantation Proceedings·S P SteigerwaltR Provenzano
Sep 14, 2006·Transplantation·Akinlolu O Ojo