Ambulatory blood pressure variability and risk of cardiovascular events, all-cause mortality, and progression of kidney disease.

Journal of Hypertension
Jong Hyun JheeTae-Hyun Yoo

Abstract

Association between blood pressure (BP) variability and cardiovascular outcome remains unclear in patients with chronic kidney disease (CKD). We evaluated this association between ambulatory BP variability and cardiovascular events, mortality, and kidney disease progression in patients with CKD. From the Cardiovascular and Metabolic Disease Etiology Research Center-HIgh Risk study (2013-2018), a total of 470 patients with CKD were analyzed. Ambulatory BP variability was assessed using average real variability (ARV). Primary outcome was composite of nonfatal myocardial infarction, nonfatal stroke, and all-cause mortality. The secondary outcome was rapid kidney function decline [estimated glomerular filtration rate (eGFR), >3 ml/min per 1.73m per year]. During a median follow-up of 51.8 (40.5-56.2) months, the incidences of all-cause death and composite outcomes were higher in the high SBP-ARV group than in the low SBP-ARV group. The Kaplan-Meier analysis showed that a high SBP-ARV, but not a high DBP-ARV and heart rate-ARV, was associated with higher composite outcome risks. In multivariable Cox analysis, a high SBP-ARV correlated with increased composite outcome risks (hazard ratio, 4.53; 95% confidence interval, 1.41-14.58). W...Continue Reading

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Citations

Mar 13, 2021·Journal of the American College of Cardiology·George Bakris, Hillel Sternlicht
Aug 4, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·David E KandzariEric Secemsky
Jan 15, 2022·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Minjae YoonSungha Park
Jan 1, 2022·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anne Pavy-Le TraonJacques Amar

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