Ambulatory management of pulmonary embolism: a pragmatic evaluation

Journal of Thrombosis and Haemostasis : JTH
Michael J KovacsA Lazo-Langner

Abstract

Patients diagnosed with pulmonary embolism should be considered for treatment on an outpatient basis; however, this practise is not accepted in many centers. Review the safety and efficacy of ambulatory management of patients with pulmonary embolism at our institution. This was a retrospective single center cohort study of consecutive patients diagnosed with idiopathic or secondary pulmonary embolism between January 2003 and January 2008 at the London Health Sciences Centre in London, Ontario, Canada. Patients were eligible for outpatient management of pulmonary embolism if they were hemodynamically stable, did not require oxygen therapy, did not require parenteral narcotics for pain management, and were not felt to be high risk for a major hemorrhage. Patients were assessed at 3 months for thrombosis recurrence and major bleeding episodes. Six hundred and thirty-nine patients were included in the study, of which 314 (49.1%; 95% CI 45.2, 53.1) were managed as outpatients; among these there were three (0.95%; 95% CI, 0.25, 3) thrombotic recurrences and three hemorrhagic events. There were nine deaths (2.9%; 95% CI, 1.4, 5.6), all due to underlying cancer and all occurring after the first 7 days of treatment. Outpatient managemen...Continue Reading

References

Feb 1, 1987·AJR. American Journal of Roentgenology·G S DorfmanC H Lee
Sep 4, 1997·The New England Journal of Medicine·UNKNOWN Columbus InvestigatorsR Baildon
Jan 1, 1995·Journal of Thrombosis and Thrombolysis·C Jerjes-SanchezE Rosas
Jul 11, 2003·The New England Journal of Medicine·Agnes Y Y LeeUNKNOWN Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Veno
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Oct 7, 2005·European Heart Journal·Drahomir AujeskyMichael J Fine
Aug 30, 2008·Clinical Medicine : Journal of the Royal College of Physicians of London·Paul AylinDerek Bell
Nov 8, 2008·Thrombosis and Haemostasis·Muhammad JanjuaPaul D Stein
Nov 17, 2009·American Journal of Respiratory and Critical Care Medicine·Olivier SanchezGuy Meyer

❮ Previous
Next ❯

Citations

Feb 19, 2011·Journal of Thrombosis and Thrombolysis·Michael B Streiff
Oct 30, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thiago Horta SoaresSuely Meireles Rezende
Dec 7, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Geert-Jan GeersingKarel G M Moons
Jun 16, 2015·Current Medical Research and Opinion·Craig I ColemanThomas J Bunz
Jan 22, 2013·The American Journal of Medicine·John FanikosSamuel Z Goldhaber
Oct 29, 2011·The Medical Clinics of North America·James M Hunt, Todd M Bull
Oct 16, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Lauren M WestaferWilliam K Milne
May 8, 2015·Thrombosis and Haemostasis·Christopher M Hillis, Mark A Crowther
Jun 30, 2011·Thrombosis and Haemostasis·Carmen VenetzDrahomir Aujesky
Oct 24, 2012·Journal of Thrombosis and Haemostasis : JTH·P L den ExterM V Huisman
Jan 22, 2011·Journal of Thrombosis and Haemostasis : JTH·T Baglin
Jun 8, 2011·Journal of Thrombosis and Haemostasis : JTH·W ZondagUNKNOWN Hestia Study Investigators
Jan 23, 2013·Journal of Thrombosis and Haemostasis : JTH·W ZondagUNKNOWN Hestia Study Investigators
Jun 2, 2011·American Journal of Hematology·Mariette J AgterofDouwe H Biesma
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·G MeyerO Sanchez
Jun 7, 2015·Journal des maladies vasculaires·A Payerols-TernisienJ-P Galanaud
Feb 20, 2015·Annals of the American Thoracic Society·David R VinsonUNKNOWN Kaiser Permanente Clinical Research on Emergency Services and Treatment (CREST) Network
Apr 19, 2015·Respiratory Research·Andrew J SchisslerAndrew J Einstein
Jun 20, 2014·Journal of Thrombosis and Thrombolysis·J E ElfM Bajc
Apr 25, 2016·The American Journal of Medicine·Paul D SteinMary J Hughes
May 22, 2016·Thrombosis Research·A Carmona-BayonasUNKNOWN Asociación de Investigación de la Enfermedad Tromboembólica de la Región de Murcia
Oct 31, 2015·Thoracic Surgery Clinics·Michael S MulliganRyan V Abbaszadeh
Oct 30, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Paul D SteinMary J Hughes
Nov 21, 2014·The Cochrane Database of Systematic Reviews·Hugo H B YooRegina El Dib
Nov 14, 2018·Annals of Internal Medicine·David R VinsonUNKNOWN eSPEED Investigators of the KP CREST Network
Nov 16, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Erin R Weeda, Sofia Butt
Oct 30, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wei-Ying JenYen-Lin Chee
Mar 7, 2019·The Cochrane Database of Systematic Reviews·Hugo Hb YooCathryn Broderick
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Rachel Limbrey, Luke Howard
Feb 2, 2012·Expert Review of Cardiovascular Therapy·Jeffrey B GeskeSunil V Mankad
Jul 8, 2019·International Journal of Epidemiology·David MetcalfeDaniel C Perry
Jun 8, 2017·International Journal of Emergency Medicine·Srinivas R BanalaKumar Alagappan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.