Abstract
To assess the ameliorative activity of polyphenolic-rich extracts of Basella rubra leaves on β-cell dysfunction in type-II diabetes (T2DM). Total phenolic and flavonoid contents; α-amylase and α-glucosidase inhibitory actions and qualitative analysis of the bioactive compounds of the polyphenolic-rich extract of B. rubra leaves were investigated using gas chromatography-mass spectroscopy (GC-MS). Diabetes mellitus (DM) was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and the rats were orally given bound phenolic (BPE) and free phenolic extracts (FPE) of B. rubra (B.R) leaves at 200 and 400 mg/kg b.w once daily for 14 days. Biochemical analyses were executed for evaluation of serum insulin, serum lipid profile concentrations, liver enzymes activities. The extracts demonstrated antioxidant potentials and enzymes inhibitory activities in dose dependent manner; and several bioactive compounds as revealed by GC-MS. BPE and FPE considerably (p<0.05) reduced hyperglycemia, improved serum insulin levels, ameliorated the concentration of serum lipid profiles and improved liver antioxidant activities. Additionally, BPE and FPE expressively decreased alanine aminotransferases (ALT), aspartate aminot...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·F Shahidi, P K Wanasundara
Jan 1, 1987·Free Radical Biology & Medicine·G Minotti, S D Aust
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Mar 1, 1997·Experimental Physiology·H Sies
Jul 13, 1999·General Pharmacology·M A GyamfiY Aniya
Oct 31, 2002·Journal of Agricultural and Food Chemistry·Yi-Fang ChuRui Hai Liu
Nov 28, 2002·Journal of Agricultural and Food Chemistry·Jie SunRui Hai Liu
Aug 19, 2003·Annals of the Rheumatic Diseases·M BoersSj van der Linden
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Mar 1, 1960·Journal of Clinical Pathology·J K FAWCETT, J E SCOTT
Apr 28, 2004·Diabetes Care·Sarah WildHilary King
May 1, 2007·Digestive Diseases·Nicoletta GaglianoGiorgio Annoni
Jul 27, 2007·Journal of Medicinal Food·Y-I KwonK Shetty
May 4, 2010·Journal of Ethnopharmacology·Nisarat SiriwatanametanonMichael Heinrich
Nov 28, 2012·Neurochemical Research·Ganiyu ObohStephen A Adefegha
Oct 13, 2015·Journal of Ethnopharmacology·Aminu MohammedMd Shahidul Islam
Apr 20, 2018·Advanced Pharmaceutical Bulletin·Basiru Olaitan AjiboyeOluwafemi Ogunmodede
May 15, 2018·Journal of Evidence-based Integrative Medicine·Basiru O AjiboyeAliyu O Amuzat
Jun 5, 2018·Antioxidants·Oluwafemi Adeleke OjoAbidemi Paul Kappo
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Jun 7, 2020·Journal of Endocrinological Investigation·B O AjiboyeA P Kappo