Ameliorating attention problems in children with sickle cell disease: a pilot study of methylphenidate.

Journal of Developmental and Behavioral Pediatrics : JDBP
Brian DalySherron Jackson

Abstract

This pilot study examined whether methylphenidate (MPH) was effective in enhancing cognitive performance and attention for children with sickle cell disease (SCD) with cerebrovascular complications who evidence attention problems. In this multisite, pilot study, we evaluated 2 separate double-blind controlled clinical trials, including a laboratory trial of the short-term efficacy of MPH, with the second study a 3-week home/school crossover trial evaluating the efficacy of MPH. The laboratory trial included 14 participants between the age of 7 and 16 years. Assessments included measures of sustained attention, reaction time, executive functions, and verbal memory. The home/school trial included 20 participants. The outcome measures were parent and teacher ratings of attention. The first study compared MPH with placebo, while the second trial compared placebo, low-dose (LD) MPH, and moderate-dose MPH. In the laboratory trial, significant effects were revealed for measures of memory and inhibitory control. Parent and teacher reports from the home/school trial indicate that moderate-dose MPH produced superior improvement in attention relative to the placebo and LD MPH. Stimulant medication positively impacted select measures of me...Continue Reading

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Citations

Nov 1, 2016·Annals of Hematology·Luise BurkhardtPablo Hernáiz Driever
May 26, 2017·Journal of Pediatric Hematology/oncology·Melissa A AcquazzinoJohn Paul Scott
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Monika R AsnaniDamian K Francis
Feb 28, 2020·British Journal of Haematology·Jeanelle S AliJane E Schreiber
Apr 8, 2021·Journal of Pediatric Psychology·Steven J HardyKristina K Hardy
Aug 17, 2021·Journal of Developmental and Behavioral Pediatrics : JDBP·Eboni I LanceJames F Casella

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