PMID: 9441129Jun 1, 1997Paper

Ameliorating effect of erythromycin on bleomycin-induced pulmonary fibrosis: role of alveolar macrophage activation and cytokine release

Respirology : Official Journal of the Asian Pacific Society of Respirology
B ChenX M Hou

Abstract

The objective of this study was to evaluate the effectiveness of erythromycin (EM) on bleomycin-induced pulmonary fibrosis in rats and its possible mechanisms. Seventy-five rats were divided into three groups. Alveolar macrophages (AM) were harvested through bronchalveolar lavage (BAL) and consecutive changes of tumour necrosis factor-alpha (TNF-alpha) and platelet-derived growth factor (PDGF) in AM supernatant and bronchoalveolar lavage fluid (BALF) were assayed with ELISA and bioassay, respectively. The AM-derived TNF-alpha was elevated on day 3, peaked day 7 and then decreased but remained at higher level until day 28. The AM-derived PDGF was increased on day 3, peaked on day 7 then decreased to non-statistically significant higher level. The TNF-alpha in BALF was increased significantly on day 3 then decreased to normal level; the peak preceded that of AM-derived TNF-alpha. The PDGF in BALF was increased on day 3, peaked on day 7, and then decreased to normal, which exhibited a consecutive change similar to that of AM-derived PDGF. The EM significantly suppressed TNF-alpha and PDGF release by AM, markedly decreased TNF-alpha and PDGF levels in BALF. The EM also lessened the collagen deposition, the lung hydroxyproline compr...Continue Reading

References

Mar 1, 1991·Chest·J A Elias, R Kotloff
Sep 1, 1989·The Journal of Experimental Medicine·P F PiguetP Vassalli
Jan 1, 1985·Journal of Leukocyte Biology·E J Kovacs, J Kelley
Dec 1, 1993·American Journal of Respiratory Cell and Molecular Biology·J WalshJ Kelley
Jan 1, 1993·The American Review of Respiratory Disease·J KadotaK Hara

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Citations

Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb

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