Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats

Canadian Journal of Physiology and Pharmacology
Gen YamamotoKazuo Takahama

Abstract

We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague-Dawley rats. Cerebral infarction was then induced by occlusion of the left middle cerebral artery. Twenty-four hours after cerebral infarction, the effect of each drug on micturition disorder was estimated for 5 parameters: bladder capacity, maximum voiding pressure, micturition latency, flow rate, and urethral resistance. Cerebral infarction markedly reduced bladder capacity, micturition latency, and flow rate and increased urethral resistance. After cerebral infarction, intravenous dosing of saline had no effect on these parameters. Dextromethorphan (20 mg/kg) and cloperastine (2.5 and 5.0 mg/kg) at antitussive effective doses significantly increased bladder capacity and micturition latency. Unlike dextromethorphan, cloperastine ameliorated decreases in flow rate and increases in urethral resistance caused by cerebral infarction. These results suggest that cloperastine may have therapeutic value for the treatment of disorders of the micturition reflex associated wit...Continue Reading

References

Jul 2, 1998·The Journal of Urology·O YokoyamaM Namiki
Jun 2, 2000·Experimental Neurology·O YokoyamaW C de Groat
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura
Sep 23, 2003·European Urology·Rikard PehrsonKarl Erik Andersson

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Citations

May 13, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuaki KawauraKazuo Takahama
Apr 7, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Gen YamamotoKazuo Takahama
Feb 20, 2016·Pharmacology, Biochemistry, and Behavior·Fumio SoedaKazuo Takahama

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