Ameliorating Effects of Lithium on the Perinatal Ethanol-induced Behavioral and Cognitive Dysfunction and Brain Oxidative Stress in Postnatal Developing Mice Pups

Current Pharmaceutical Biotechnology
Mohammad Ahmad, Gasem M Abu Taweel

Abstract

Developmental ethanol (EtOH) exposure can cause lifelong behavioral hyperactivity, cognitive deficits, emotional dysregulation, and more. However, co- treatment with lithium (Li) on the day of EtOH exposure prevents many of the impairments. Experimental groups of pregnant mice were exposed to EtOH (20% v/v solution at a dose of 2.5 g/kg) in their drinking water and the animals were treated with Li (15 and 30 mg/kg) through ipinjection on gestational days14, 16, 18, and 20, and post-natal days (PD) 3, 5, 7, and 9. All treatments with EtOH and exposure to Li doses to mothers started on gestational day 14 and continued until post-natal day 9 (PD9). The effects on some developing morphological indices, nerve reflexes during weaning age and various cognitive dysfunctions at adolescent ages and biochemical changes in the brain tissue indices of below mentioned neurotransmitters and oxidative stress at post-natal developing offspring at adolescent age, were studied. Perinatal exposure to EtOH in pregnant mice resulted in several postnatal developing and morphological indices in the developing male pups during their weaning period, like gain in their body weight, delay in appearance of their body hair fuzz and opening of their eyes, an...Continue Reading

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