Amelioration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease

Behavioural Pharmacology
Mohammad Moshahid KhanFakhrul Islam

Abstract

Increased oxidative stress is implicated in the pathogenesis of Parkinson's disease in which dopaminergic neurons are intrinsically susceptible to oxidative damage. Swiss albino mice were pretreated with Pycnogenol (PYC), an extract of Pinus maritime bark [20 mg/kg body weight, intraperitoneally (i.p.)] once daily for 15 days. Thereafter, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg body weight, intraperitoneally) was given four times at 2-hour intervals on 1 day only. Behaviours were altered in the MPTP group as compared with the vehicle-treated group and were restored in the PYC-pretreated MPTP group. The activity of antioxidant enzymes and the content of glutathione were significantly depleted in the MPTP-induced Parkinsonian group. The MPTP group pretreated with PYC showed significant protection of the activity of antioxidant enzymes and glutathione content when compared with the vehicle-treated MPTP group. A significantly elevated level of thiobarbituric acid reactive substances in the MPTP group was decreased significantly in the animals pretreated with PYC. An increase in the number of dopaminergic D2 receptors and decrease in the level of dopamine and its metabolite 3,4-dihydroxyphenyl acetic acid in th...Continue Reading

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Citations

Aug 15, 2013·Journal of Molecular Neuroscience : MN·Karamkolly R RekhaRamu Inmozhi Sivakamasundari
Apr 11, 2015·Pharmaceutical Biology·Sangeetha NagarajanSenthilkumar Thulasingam
Jan 4, 2012·Journal of Ethnopharmacology·Ju-Xian SongYan-Bo Zhang
Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Jana Trebatická, Zdeňka Ďuračková
Nov 16, 2018·The International Journal of Neuroscience·Mani SugumarSathiya Sekar

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