Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation.

Toxicological and Environmental Chemistry
David ClarkeBoyd E Haley

Abstract

The toxic effects of mercury are known to be complex with specific enzyme inhibitions and subsequent oxidative stress adding to the damaging effects. There are likely other factors involved, such as the development of impaired metal ion homeostasis and depletion of thiol and selenium based metabolites such as cysteine and selenium. Much of the toxicity of mercury occurs at the intracellular level via binding of Hg(2+) to thiol groups in specific proteins. Therefore, amelioration of mercury toxicity by the use of chelation would likely be enhanced by the use of a chelator that could cross the cell membrane and the blood brain barrier. It would be most favorable if this compound was of low toxicity, had appropriate pharmacokinetics, bound and rendered mercury cation non-toxic and had antioxidant properties. Herein we report on such a chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI), and, using an animal model, show that it prevented the toxic effects associated with acute exposure induced by injected mercury chloride.

Associated Clinical Trials

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Citations

Jun 17, 2018·Basic & Clinical Pharmacology & Toxicology·Johan L Å NilssonLars Grundemar
Feb 16, 2018·Environmental Health : a Global Access Science Source·Paul SchutzmeierStephan Bose-O'Reilly
Jun 1, 2016·Assay and Drug Development Technologies·Hermann A M Mucke
Dec 10, 2019·Antioxidants & Redox Signaling·Nivedita SarkarDona Sinha
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ann SusanUma Maheswari Krishnan

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