PMID: 7539741Mar 1, 1995Paper

Amelioration of bleomycin-induced lung fibrosis by treatment with the platelet activating factor receptor antagonist WEB 2086 in hamsters

Experimental Lung Research
S N GiriJ S Wild

Abstract

Therapeutic use of bleomycin, an antineoplastic drug, is complicated by the development of a dose-dependent lung toxicity leading to fibrosis. This study tested the effectiveness of a platelet activating factor (PAF) receptor antagonist, WEB 2086, against bleomycin (BLEO)-induced lung fibrosis in hamsters. The animals were assigned to four groups: (1) saline (SA) + SA, (2) WEB 2086 (WEB) + SA, (3) SA + BLEO, and (4) WEB + BLEO. Sterile isotonic saline or WEB 2086 (10 mg/kg IP) was administered daily for the duration of the study starting 2 days prior to intratracheal (IT) instillation of saline or bleomycin (2.5, 2.0, and 1.5 units/kg 5 mL-1) in three consecutive doses at weekly intervals. The animals were killed at 21 days after the last IT instillation and their lungs were processed for various studies. The lung hydroxyproline levels in SA + SA, WEB + SA, SA + BLEO, and WEB + BLEO groups were 932 +/- 31, 943 +/- 48, 1302 +/- 72, and 964 +/- 63 micrograms/lung, respectively. The lung myeloperoxidase (MPO) activity and malondialdehyde equivalent, an index of lipid peroxidation, in the corresponding groups were 10 +/- 2, 8 +/- 2, 14 +/- 3, and 5 +/- 1 units/lung and 93 +/- 7, 77 +/- 5, 102 +/- 8, and 75 +/- 6 nmol/lung, respecti...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 5, 1979·The New England Journal of Medicine·D J ProckopN A Guzman
May 1, 1992·American Journal of Respiratory Cell and Molecular Biology·D M HydeC G Plopper
Jun 14, 1991·Biochemical and Biophysical Research Communications·T SchabergH Lode
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Mar 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M B Garnick
Dec 1, 1985·Journal of Applied Physiology·S E GoldblumM Jay
Dec 1, 1986·The Journal of Clinical Investigation·A J WardlawA B Kay
Feb 1, 1987·European Journal of Clinical Investigation·C CarameloL Hernando
Jul 1, 1987·Toxicology and Applied Pharmacology·K M ReiserJ A Last
Sep 1, 1987·The American Review of Respiratory Disease·K R StenmarkR C Murphy
Jul 1, 1970·Archives of Biochemistry and Biophysics·R L Miller, S Udenfriend
Sep 1, 1982·Acta Physiologica Scandinavica·L LindbomK E Arfors
Jan 1, 1983·International Review of Connective Tissue Research·J G ClarkR P Mecham
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Jan 1, 1992·Mediators of Inflammation·A Rodriguez-BarberoJ M López-Novoa

❮ Previous
Next ❯

Citations

Jan 1, 2001·Environmental Health and Preventive Medicine·Q ZhangH Zhong
Jun 1, 1997·Journal of Lipid Mediators and Cell Signalling·J Chen, N Giris
Jan 24, 2003·Annual Review of Pharmacology and Toxicology·Shri N Giri
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·T YehualaeshetN Khalil
Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb
Feb 17, 2005·European Journal of Pharmacology·Azza El-MedanyGamila El-Medany
May 28, 2015·The Journal of Nutritional Biochemistry·Marina Chaves de OliveiraAdaliene Versiani Matos Ferreira
Aug 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohamed H DabaHassan A El-Kashef
Jun 16, 2012·The Clinical Respiratory Journal·Ole HilbergElisabeth Bendstrup
Aug 25, 2018·Archives of Pathology & Laboratory Medicine·Francesca LunardiFiorella Calabrese
Nov 19, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·José Baddini-MartinezRogério Rufino
Feb 28, 2002·British Journal of Pharmacology·Stevo MirkovicLindsay Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.