PMID: 25753886Mar 11, 2015Paper

Amelioration of cardiotoxic impacts of diclofenac sodium by vitamin B complex

European Review for Medical and Pharmacological Sciences
N A AbdulmajeedA M Mohamed

Abstract

The safety of Non-steroidal anti-inflammatory drugs (NSAIDs) use in clinical practice has been questioned. Clinical studies indicate that these drugs cause adverse cardiovascular effects. The aim of this study was to investigate the protective role of vitamin B complex against the cardiotoxic potency of diclofenac sodium induced cardiac damage. Diclofenac sodium was administered intraperitoneally to rats at either 1.5 mg or 3 mg/kg body weight for 14 consecutive days. Vitamin B complex (1.6 mg B1, 1.6 mg B6 and 16.7 µg B12/kg body weight, i.p.) was co-administered daily for 3 weeks along with diclofenac administration to rats intoxicated by either of the two doses. The results revealed that co-administration of vitamin B complex with diclofenac to rats intoxicated by either of the two doses, markedly ameliorated increases in serum markers of cardiac damage, including, (AST), creatine kinase-MB (CK-MB) as well as decreases in phosphoglucoisomerase (PGI) and lactate dehydrogenase (LDH) activities in cardiac tissue compared with intoxicated rats. The B complex also could markedly attenuate the decreases in cardiac antioxidant enzymes namely, glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G-6-PDH) and catalase (CAT)...Continue Reading

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