Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of Bauhinia purpurea: An in vivo study in rats

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Md Azmat RanaAijaz Ahmed Khan

Abstract

Our objective is to study the nephroprotective activity and antioxidant potential of Bauhinia purpurea unripe pods and bark against cisplatin-induced nephrotoxicity. Healthy adult albino rats of either sex (150-200 g) were randomly divided into six groups of six animals each Group I (vehicle control) and Group II (negative control). Group III (BBE200) and Group IV (BBE400) were administered the ethanolic extract of Bauhinia purpurea bark in doses of 200 and 400 mg/kg/day p.o., respectively, and Group V (BPE200) and Group VI (BPE400) were administered the ethanolic extract of Bauhinia purpurea unripe pods at doses of 200 and 400 mg/kg/day p.o., respectively. All the treatments were given for nine days. Cisplatin in a single dose of 6 mg/kg i.p. was given on the 4 th day to all groups, except the vehicle control group. On the 10 th day, blood and urine were collected for biochemical tests and the rats were sacrificed. The kidney was removed for histology and lipid peroxidation-antioxidant test. Cisplatin caused nephrotoxicity as evidenced by elevated blood urea, serum creatinine and urine glucose, and there was decreased creatinine clearance in Group II as compared with Group I. Administration of BBE and BPE at doses of 200 and 4...Continue Reading

References

Jun 1, 1972·Analytical Biochemistry·A K Sinha
Jun 17, 1998·The Journal of Laboratory and Clinical Medicine·H MatsushimaA Hishida
Oct 3, 1999·Kidney International·A H Lau
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·J T HartmannC Bokemeyer
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Feb 15, 2005·Journal of Ethnopharmacology·M OgeturkM Sarsilmaz
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Oct 6, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Zainul Amiruddin ZakariaHanan Kumar Gopalan
May 27, 2010·Indian Journal of Pharmaceutical Sciences·B V S LakshmiM Sudhakar
Nov 10, 2011·Toxins·Ronald P MillerWilliam Brian Reeves
Jul 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Sara S SantosLetícia Cruz

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Citations

Aug 9, 2020·Environmental Science and Pollution Research International·Azza M A Abo-ElmaatyMohamed M Abdel-Daim

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