Amelioration of collagen II-induced arthritis in rats by the type IV phosphodiesterase inhibitor Rolipram

Clinical and Experimental Immunology
U NymanL Klareskog

Abstract

The effect of Rolipram, a selective inhibitor of the cyclic AMP specific phosphodiesterase (PDE IV) was evaluated in the rat collagen type II (RCII)-induced arthritis model in the DA rat. Rolipram was given either shortly before expected onset of disease (days 10-14) or shortly after the onset of clinically evident arthritis (days 15-19 after immunization). Administration at days 10-14 delayed the onset of arthritis for approximately 5 days, but the severity of arthritis was thereafter comparable to that seen in a non-treated control group. Rolipram treatment of animals with manifest arthritis inhibited further arthritis development and also tended to diminish its severity at a phase of disease where non-treated control animals showed a rapidly progressing disease development. Serum levels of antibodies to RCII were in all experiments similar between Rolipram-treated and control animals. An in situ hybridization method for determining cytokine mRNA synthesis in regional lymph nodes, after administration of Rolipram (at days 2-7), demonstrated a strong inhibitory effect on tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNA expression, whereas no effects were seen on IL-2 mRNA synthesis after in vivo c...Continue Reading

Citations

Oct 29, 2000·Annals of the Rheumatic Diseases·M FeldmannR N Maini
Sep 25, 2009·Multiple Sclerosis : Clinical and Laboratory Research·Bibiana BielekovaRoland Martin
Dec 19, 2003·Arthritis Research & Therapy·Farideh EskandariEsther M Sternberg
Mar 17, 1999·European Journal of Pharmacology·M XiangF Nicoletti
Apr 11, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·A LamprechtY Kawashima
Jul 5, 2005·Expert Opinion on Investigational Drugs·H J Dyke, J G Montana
Feb 13, 2010·Autoimmunity Reviews·Padmanabha Shenoy, Vikas Agarwal
Jan 26, 2007·European Journal of Pharmacology·Satoshi YamamotoYasuaki Shimizu
Sep 30, 2005·International Journal of Experimental Pathology·Richard O WilliamsPercy F Sumariwalla
Dec 18, 2003·Immunology·Patricia OzegbeRichard O Williams
May 23, 2015·BioMed Research International·Zhi-cheng ZhangQiang-min Xie
Jul 27, 1999·Current Opinion in Chemical Biology·A M Doherty
Jul 24, 2004·Journal of Pharmacological Sciences·Takashi KyoiYojiro Ukai
Nov 29, 2011·Survey of Ophthalmology·Khayyam DurraniC Stephen Foster
Jul 3, 2004·The Journal of Pharmacy and Pharmacology·Hoda E MohamedTamer M Abd el-Fattah
Aug 21, 2010·Zeitschrift für Rheumatologie·M GrünkeG-R Burmester
Aug 7, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Maria P GiovannoniVittorio Dal Piaz
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Florian LoherAndreas Eigler
Mar 31, 2000·Current Opinion in Pulmonary Medicine·M S Barnette, D C Underwood
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Oct 29, 2005·The Journal of Pharmacology and Experimental Therapeutics·S VidelaJ-R Malagelada
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BielekovaR Martin

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