Amelioration of diabetes-induced testicular and sperm damage in rats by cerium oxide nanoparticle treatment

Andrologia
Tayebe ArtimaniSaeid Afshar

Abstract

Cerium oxide nanoparticles (CNPs) as an antioxidant have been used frequently to attenuate hyperglycaemia oxidative damage in different organs. We investigated the impact CNPs on the qualitative and quantitative sperm parameters, spermatogenesis and NFE2-related factor 2 (Nrf2) expression as a major contributor of antioxidant defence in the male diabetic rats. Twenty-four male rats were divided into four groups. Controls received only mouse food and water. Second group were treated with CNPs (30 mg kg-1  day-1 ) for 2 weeks. Rats in third group received streptozotocin (STZ) (60 mg/kg). In fourth group, animals became diabetic and received CNPs (30 mg kg-1  day-1 ) for 2 weeks. The results showed a significant abnormality in the sperm parameters and histopathological patterns of testes in the diabetic group compared to the control group and CNPs treatment significantly improved all testicular parameters. Following CNPs administration, sperm DNA fragmentation significantly reduced in the STZ-treated rats. Moreover, after CNPs intake in the STZ-treated rats, Nfr2 expression levels increased significantly. Overall, CNPs administration on the diabetic rates can attenuate detrimental effects of diabetes on the sperm potential fertili...Continue Reading

References

Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Oct 6, 2009·Small·Suzanne M HirstChristopher M Reilly
Apr 7, 2010·Antioxidants & Redox Signaling·Nobunao WakabayashiThomas W Kensler
Aug 10, 2010·Free Radical Biology & Medicine·Brooke N NakamuraUlrike Luderer
Apr 9, 2011·Journal of Andrology·Sandro La VigneraAldo E Calogero
Nov 15, 2011·Diabetes Research and Clinical Practice·David R WhitingJonathan Shaw
Oct 24, 2012·The Tohoku Journal of Experimental Medicine·Kang ChenBolan Yu
Apr 10, 2013·Acta Cirúrgica Brasileira·Amélia Arcângela Teixeira TrindadeCésar Tadeu Spadella
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 22, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Natalia BarkalinaKevin Coward
Feb 25, 2014·Redox Report : Communications in Free Radical Research·Sih Min Tan, Judy B de Haan
Mar 26, 2014·Tissue Barriers·Marco G AlvesPedro F Oliveira
May 30, 2014·The World Journal of Men's Health·Ashok AgarwalStefan S du Plessis
May 31, 2014·Biochemical and Biophysical Research Communications·Yongde XuZhongcheng Xin
Jun 13, 2014·Current Diabetes Reviews·Ram Niwas Jangir, Gyan Chand Jain
Mar 31, 2015·Asian Journal of Andrology·Guo-Lian DingHe-Feng Huang
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed A DkhilAhmed E Abdel Moneim
Mar 8, 2017·Oxidative Medicine and Cellular Longevity·Cheng LiJian Sun

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Citations

Mar 22, 2019·Journal of Nanobiotechnology·Fenju QinJian Tong
Jul 12, 2019·Journal of Nanobiotechnology·Neelam ThakurJoydeep Das
Sep 30, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Robert A YokelEric A Grulke
Mar 28, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Wui Fang Chai, Kim San Tang
Apr 10, 2021·Drug and Chemical Toxicology·Saadet Özen Akarca DizakarAkın Tekcan
Jul 18, 2021·Biopreservation and Biobanking·Maryam HosseinmardiMaryam Hezavehei
Aug 8, 2021·International Journal of Molecular Sciences·Mariana VassalMaria de Lourdes Pereira

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