Amelioration of Escherichia coli-induced endometritis with ascorbic acid in non-pregnant mouse models

American Journal of Reproductive Immunology : AJRI
Enitome Evi BaforOsas Jim Eghianruwa

Abstract

Infection-induced endometritis is associated with infertility. The outcome with oral antibiotics remains poor. This study therefore investigates the role of ascorbic acid in resolving endometritis. Animals with established oestrus cycles were inoculated with Escherichia coli. Two days post-inoculation, the animals were administered ascorbic acid (10, 100 and 1000 mg/kg) and amoxicillin (500 mg/kg) for 5 days. Other groups included water only and E. coli inoculated with no treatment. Body temperatures, weights and vaginal cytology were examined. On the sixth day, after anaesthesia, blood samples were obtained for haematological analysis. Uterine organs were weighed, ex-vivo functionality analysed and histopathological analysis performed. Ascorbic acid (AA) (100 and 1000 mg/kg) regularized the cycle of the endometritic animals comparable to amoxicillin. AA (1000 mg/kg) and amoxicillin, significantly decreased (P < .05) the endometritis-induced increase in uterine weights, restored the endometrial architecture and significantly (P < .05) normalized uterine contractions to control values. Improved haematological profiles were additionally observed on treatment with ascorbic acid (100 and 1000 mg/kg). AA compared favourably with amo...Continue Reading

References

Aug 1, 1978·Fertility and Sterility·B Czernobilsky
Dec 1, 1991·The American Journal of Clinical Nutrition·B E Haskell, C S Johnston
May 12, 1973·British Medical Journal·M J TikkanenM O Pulkkinen
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·M A Sahud, P M Aggeler
Dec 1, 1995·The American Journal of Clinical Nutrition·H Sies, W Stahl
Mar 18, 2000·Scandinavian Journal of Immunology·P M WongB M Sultzer
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Takumi TaniguchiKen Yamamoto
Dec 9, 2003·Mechanisms of Ageing and Development·Hiroshi SaitoB Mark Evers
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Daniel G Remick, Hongyan Xioa
Jul 29, 2006·Journal of Clinical Pathology·W G McCluggage
Oct 28, 2008·Free Radical Biology & Medicine·Gladys BlockPaul Harmatz
Dec 2, 2008·Acta Tropica·Marcela Arteaga-SilvaJorge Morales-Montor
Feb 17, 2009·Fertility and Sterility·Erika B Johnston-MacAnannyClaudio A Benadiva
Jul 4, 2009·Current Protocols in Neuroscience·Claudia S Caligioni
Feb 26, 2010·The American Journal of Clinical Nutrition·Gertruud Cm BakkerHenk Fj Hendriks
Jun 9, 2012·Obstetrics and Gynecology·Harold C WiesenfeldRichard L Sweet
Oct 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James L HutchinsonJane E Norman
Jan 28, 2014·Fertility and Sterility·Dana B McQueenMary D Stephenson
Jul 16, 2014·The International Journal of Developmental Biology·Justyna Filant, Thomas E Spencer
Oct 22, 2014·American Journal of Reproductive Immunology : AJRI·Daojun XuQing Yang
Oct 20, 2015·American Journal of Reproductive Immunology : AJRI·Kotaro KitayaHisao Yamada
Nov 15, 2017·American Journal of Reproductive Immunology : AJRI·Ettore CicinelliLeonardo Resta

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Citations

Jan 27, 2019·American Journal of Reproductive Immunology : AJRI·Zhifeng JiaBo Liu

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