Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients

Adipocyte
Bjorn EliassonJian Yang

Abstract

Early studies reported that the size of adipose cells positively correlates with insulin resistance, but recent evidence suggests that the relationship between adipose cell size and insulin resistance is more complex. We previously reported that among BMI-matched moderately obese subjects who were either insulin sensitive or resistant insulin resistance correlated with the proportion of small adipose cells, rather than the size of the large adipose cells, whereas the size of large adipose cells was found to be a predictor of insulin resistance in the first-degree relatives of type 2 diabetic (T2D) patients. The relationship between adipose cellularity and insulin resistance thus appears to depend on the metabolic state of the individual. We did a longitudinal study with T2D patients treated with the insulin-sensitizer rosiglitazone to test the hypothesis that improved insulin sensitivity is associated with increased adipocyte size. Eleven T2D patients were recruited and treated with rosiglitazone for 90 days. Blood samples and needle biopsies of abdominal subcutaneous fat were taken at six time points and analyzed for cell size distributions. Rosiglitazone treatment ameliorated insulin resistance as evidenced by significantly d...Continue Reading

References

Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Jan 31, 2002·Annual Review of Medicine·Roger H Unger
Jan 31, 2002·Annual Review of Medicine·Joel Berger, David E Moller
Jun 12, 2003·Metabolism: Clinical and Experimental·Guenther BodenSusan K Fried
Jun 7, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Margareta JernåsMalin Lönn
Jun 4, 2008·Annual Review of Biochemistry·Peter Tontonoz, Bruce M Spiegelman
Mar 28, 2009·PLoS Computational Biology·Junghyo JoVipul Periwal
Sep 11, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Malin LönnLauren Lissner
Oct 13, 2009·The Journal of Clinical Endocrinology and Metabolism·Tim B KoenenRinke Stienstra
Jan 29, 2010·PloS One·Jennifer MacKellarVipul Periwal
Jul 9, 2010·Lancet·Varman T SamuelGerald I Shulman
Nov 30, 2010·Biophysical Journal·Junghyo JoVipul Periwal

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Citations

Dec 23, 2015·International Immunopharmacology·Jinhui WangJingfeng Wang
Mar 9, 2018·The Journal of Experimental Biology·Panna TandonJames E N Minchin
Aug 3, 2018·Journal of Molecular Endocrinology·Louise K MetcalfeNigel Turner
Apr 19, 2020·Nature Reviews. Endocrinology·Karolien De BosscherLuc Brunsveld

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