PMID: 8996527Jan 1, 1997Paper

Amelioration of methotrexate-induced malabsorption by vitamin A

Cancer Chemotherapy and Pharmacology
J YamamotoS Awazu

Abstract

Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease. The transport of D-glucose in the small intestine of MTX plus VA- and VA-treated rats and of control rats followed Michaelis-Menten kinetics, in contrast to the transport kinetics in MTX-treated rats. The pharmacokinetics of orally administered [14C]-D-glucose in control rats and MTX- and/or VA-treated rats was also studied. The bioavailability of D-glucose in MTX-treated rats was lower than in the other three groups. VA coadministration improved the bioavailability of D-glucose. Thus, it seems likely that VA ameliorates MTX-induced malabsorption.

Citations

Jul 30, 1999·Pharmacology & Toxicology·K Hirata, T Horie
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter D ColeBarton A Kamen
Apr 20, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·D A Swartz-BasileM S Levin
Mar 10, 2001·The Journal of Nutrition·T HorieT Fuwa
Feb 18, 2006·The Journal of Nutrition·Toshiharu HorieToru Fuwa

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