Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Amir SharabiEdna Mozes

Abstract

A peptide (hCDR1) based on the sequence of the complementarity-determining region-1 of an anti-DNA autoantibody ameliorates clinical manifestations of lupus. We analyzed the beneficial effects of hCDR1 when given alone or in combination with dexamethasone, while comparing the mechanisms of action of the latter. Treatment with either hCDR1 or dexamethasone, or a combination of the latter significantly reduced titers of dsDNA-specific autoantibodies, levels of proteinuria, and intensity of glomerular immune complex deposits. Both drugs down-regulated the secretion and expression of IFN-gamma and IL-10, but only treatment with hCDR1 up-regulated TGF-beta. While both drugs reduced the expression of Fas ligand (FasL) and caspase 8, treatment with hCDR1 resulted in reduced whereas dexamethasone administration resulted in increased rate of apoptosis. Furthermore, down-regulation of FasL appeared to play a role in cytokine modulation. We conclude that specific treatment with hCDR1 ameliorates murine lupus via distinct mechanisms of action than those of dexamethasone.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S MendlovicE Mozes
Nov 17, 1995·Science·T S GriffithT A Ferguson
Dec 1, 1993·The Journal of Experimental Medicine·M R AldersonD H Lynch
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E RazD A Carson
Feb 1, 1997·Nature Medicine·K SeinoH Yagita
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·A WaismanE Mozes
Mar 25, 2000·Annals of the Rheumatic Diseases·G S DeanD A Isenberg
Apr 24, 2001·Lupus·W W Chatham, R P Kimberly
Jan 23, 2002·Cell Death and Differentiation·C W Distelhorst
Jun 5, 2003·European Journal of Immunology·Hélène Trébéden-NègreFrédéric Batteux

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Citations

Dec 14, 2011·Autoimmunity Reviews·Ram P SinghBevra H Hahn
Oct 18, 2011·Autoimmunity Reviews·Priya SawlaRam P Singh
Apr 14, 2010·Autoimmunity Reviews·Ravi K DineshRam Pyare Singh
Dec 8, 2009·Trends in Immunology·Trygve HolmøyBjarne Bogen
Jul 28, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amir SharabiEdna Mozes
Feb 5, 2008·La Presse médicale·Jean Sibilia, Jean-Louis Pasquali
Feb 4, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Reshmi ParameswaranEdna Mozes
Nov 18, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Jean Sibilia
Nov 12, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Julieta PandolfiLourdes Arruvito
Jun 6, 2020·Expert Opinion on Investigational Drugs·Rossella TalottaMagdalena Janina Laska
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir Sharabi, Edna Mozes
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ram Pyare SinghBevra H Hahn
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir SharabiEdna Mozes
Jun 8, 2021·Frontiers in Immunology·Ram P SinghDavid S Bischoff

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