Abstract
Myoglobinuric acute renal failure causes increased oxidative stress. Since ethanol upregulates renal antioxidant enzymes and wine polyphenols behave as antioxidants, we tested the hypothesis that red wine components would ameliorate the renal damage caused by rhabdomyolysis. Adult rats received water (control), alcohol-free red wine, ethanol 12.5% (v/v) or red wine for 10 weeks. Rhabdomyolysis was induced by glycerol injection (50%, 10 ml/kg, i.m.), and urine and blood samples were collected 6 h later to measure renal function parameters, creatine kinase (CK) activity, free F(2)-isoprostanes and total antioxidant capacity. Kidneys were then harvested for morphological studies and determinations of lipid peroxidation, protein carbonylation, (Na + K)-ATPase and antioxidant enzyme activities. In the control group, myoglobinuria was associated with a 68% decrease in creatinine clearance and increases in plasma creatinine and blood urea nitrogen of 3.2 and 1.8 times above baseline, respectively. Controls also showed increases in plasma free F(2)-isoprostanes levels and CK activity, together with enhanced renal expression of the antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase, as well as increased produc...Continue Reading
References
Jun 1, 1985·Analytical Chemistry·P PradellesJ Maclouf
Sep 1, 1982·The British Journal of Nutrition·I E DreostiR A Buckley
Jul 15, 1996·Analytical Biochemistry·I F Benzie, J J Strain
Jun 18, 1998·The Journal of Nutrition·M SerafiniA Ferro-Luzzi
Nov 7, 1998·European Journal of Clinical Nutrition·G G DuthieG M Steele
Nov 21, 1998·The Journal of Biological Chemistry·K P MooreL J Roberts
Feb 7, 2001·Journal of Agricultural and Food Chemistry·M S McDonaldA Crozier
Dec 10, 1999·Renal Failure·V AvramovicV Stefanovic
Jun 8, 2000·Renal Failure·V StefanovicM Mitic-Zlatkovic
Jul 25, 2000·Journal of the American Society of Nephrology : JASN·Raymond VanholderNorbert Lameire
Jan 12, 2001·Physiological Reviews·E Féraille, A Doucet
Mar 13, 2001·Journal of Cardiovascular Pharmacology·L GiovanniniA Bertelli
Aug 15, 2001·The British Journal of Nutrition·J ArayaG Rivera
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Sep 28, 2001·British Journal of Anaesthesia·J AndradeN D Edwards
Jun 21, 2002·Annals of the New York Academy of Sciences·Alberto A E BertelliLuca Giovannini
Jul 20, 2002·Free Radical Biology & Medicine·Ramón Rodrigo, Gonzalo Rivera
Sep 5, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cheryl Szebedinszky, Kathleen M Gilmour
Sep 25, 2002·Circulation·Jürgen F LeikertVerena M Dirsch
Oct 16, 2002·Life Sciences·Ramón RodrigoCleofina Bosco
Citations
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Egor Y PlotnikovDmitry B Zorov
Dec 17, 2009·Antioxidants & Redox Signaling·Barry Halliwell, Chung Yung J Lee
Apr 23, 2009·Critical Care Medicine·Yoon Sook KimSe-Ho Chang
Apr 14, 2005·Archives of Histology and Cytology·Mitsuru SaitoTomonori Habuchi
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Barbara BuffoliRita Rezzani
May 29, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P VlahovićV Stefanović
Oct 23, 2009·British Journal of Pharmacology·Mahmoud M El-MasMahmoud M Mohy El-Din
Dec 29, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ramón Rodrigo, Cleofina Bosco
May 31, 2014·Oxidative Medicine and Cellular Longevity·Laura Di RenzoAntonino De Lorenzo
Oct 5, 2010·Biochimica Et Biophysica Acta·E Y PlotnikovD B Zorov
Sep 26, 2013·Renal Failure·Ramar ManikandanMalaikannan Latha
Feb 22, 2012·Free Radical Biology & Medicine·Ludwig K GroeblerPaul K Witting
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Osama F HarrazMahmoud M El-Mas
Mar 28, 2012·European Journal of Pharmacology·Mai M Helmy, Hanan M El-Gowelli
Dec 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ramón RodrigoLeonardo Vergara
Aug 4, 2015·PloS One·Eiichiro KandaKei Nakajima
Dec 1, 2007·Electrolyte & Blood Pressure : E & BP·Seong Kwon MaSoo Wan Kim
Aug 29, 2019·Nature Reviews. Nephrology·Kristof Van AvondtSacha Zeerleder
Sep 1, 2013·Comprehensive Reviews in Food Science and Food Safety·Alaa El-Din A BekhitEric N Ponnampalam
Sep 3, 2009·Journal of Agricultural and Food Chemistry·M Soledad Fernández-PachónM Carmen García-Parrilla