Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation

Phytotherapy Research : PTR
Eitan FibachEliezer Rachmilewitz

Abstract

In beta-hemoglobinopathies, such as beta-thalassemia (thal) and sickle cell anemia, the primary defects are mutations in the beta-globin gene. However, many aspects of the pathophysiology are mediated by oxidative stress. Fermented papaya preparation (FPP), a natural health food product obtained by biofermentation of carica papaya, has been shown to limit oxidative stress both in vitro and in vivo. We studied the effect of FPP on two groups of beta-thal patients: beta-thal, major and intermedia, (in Israel) and E-beta-thal (in Singapore). The results indicated that in both groups FPP treatment increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters. Since the turnover of the erythron is relatively slow, it is possible that longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve the latter goals.

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Citations

Aug 5, 2011·Blood·Eliezer A Rachmilewitz, Patricia J Giardina
Aug 15, 2014·BioMed Research International·Paul I TyanAli T Taher
Apr 29, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Okezie I AruomaTheeshan Bahorun
Dec 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jhoti SomanahOkezie I Aruoma
May 20, 2014·Free Radical Biology & Medicine·Laura M Bystrom, Stefano Rivella
Aug 18, 2010·Annals of the New York Academy of Sciences·Eitan Fibach, Eliezer A Rachmilewitz
May 3, 2014·Archives of Pathology & Laboratory Medicine·Eiman HusseinAbeer Kamal
Nov 30, 2018·Molecular Diagnosis & Therapy·Eitan Fibach, Mutaz Dana
Jun 3, 2015·Phytotherapy Research : PTR·E Fibach, I Ginsburg
Sep 22, 2016·Antioxidants & Redox Signaling·Rhoda Elison HirschJoel M Friedman
Dec 12, 2018·Journal of Cellular Physiology·Homa NomaniAmir Hooshang Mohammadpour
Mar 7, 2021·International Journal of Molecular Sciences·Coralia CotoraciAnca Hermenean
Mar 8, 2021·Free Radical Biology & Medicine·Angela AllenStephen Allen

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