Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Mutiu Idowu KazeemM T Yakubu

Abstract

Free and bound polyphenol extracts of Zingiber officinale rhizome were investigated for their antidiabetic potential in the pancreatic and renal tissues of diabetic rats at a dose of 500mg/kg body weight. Forty Wistar rats were completely randomized into five groups: A-E consisting of eight animals each. Group A (control) comprises normal healthy animals and were orally administered 1.0mL distilled water on a daily basis for 42 days while group B-E were made up of 50mg/kg streptozotocin (STZ)-induced diabetic rats. Group C and D received 1.0mL 500mg/kg body weight free and bound polyphenol extracts respectively while group E received 1.0mL 0.6mg/kg of glibenclamide. Administration of the extracts to the diabetic rats significantly reduced (p<0.05) serum glucose and urea concentrations, increased (p<0.05) serum insulin and Homeostatic Model Assessment for β-cell dysfunction (HOMA-β) while the level of creatinine and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were not affected. Histological examination of the pancreas and kidney revealed restoration of the structural derangements caused by streptozotocin in the polyphenol extracts treated diabetic rats compared to the control groups. Therefore, polyphenols from...Continue Reading

References

Apr 16, 2002·Current Opinion in Pharmacology·Christine G Schnackenberg
Jun 2, 2004·Microscopy Research and Technique·M Daisy MythiliS Gunasekaran
Jan 19, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alice Y Y Cheng, I George Fantus
Jun 7, 2005·Lancet·Robert Beaglehole, Richard Horton
Apr 11, 2007·Archives of Internal Medicine·Dirk TaubertEdgar Schömig
May 17, 2008·Biochemical Society Transactions·Sigurd Lenzen
Sep 25, 2010·European Journal of Pharmacology·Vilapakkam Ranganathan PunithavathiJemmi Selvakumari
Mar 26, 2013·Diabetes Research and Clinical Practice·Leonor Guariguata

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Citations

Mar 30, 2016·European Journal of Pharmacology·Salah A GhareibAbdulrahman M Alahdal
May 2, 2016·Journal of Diabetes and Its Complications·Hany M El-BassossySalah A Ghareib
Feb 25, 2020·Journal of Agricultural and Food Chemistry·Zhenyu WangShaoling Lin

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