Amelioration of renal and hepatic function, oxidative stress, inflammation and histopathologic damages by Malva sylvestris extract in gentamicin induced renal toxicity

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zeynab Mohamadi YarijaniSeyed Vahid Jassemi

Abstract

Gentamycin, contrary to its wide range of antimicrobial effects, has a high potential for nephrotoxicity, and renal injury can have effects on other organs such as the liver. The aim of the present study was to assess the effects of hydro alcoholic Malva sylvestris(MS) extract on nephrotoxicity induced by gentamicin, and also its remote organ injury in the liver. Renal and hepatic functions were evaluated through measurement of creatinine, urea-nitrogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in plasma. Oxidative stress was assessed through measuring malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP) levels, and histopathologic injuries were evaluated using H & E stained sections. For evaluation of inflammation, TNF-α and ICAM-1 mRNA expression levels were measured in the renal tissue using Real-time PCR method. Gentamicin resulted in an increase in the levels of creatinine, urea-nitrogen, AST, ALT, and ALP in the plasma, as well as an increase in TNF-α and ICAM-1 mRNA expression levels in the renal tissue, renal and hepatic histopathologic injuries and MDA level, and a decrease in FRAP. Administration of MS led to improvement in the function of kidney and...Continue Reading

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Citations

Nov 13, 2019·Phytotherapy Research : PTR·Javad Sharifi-RadNatália Martins
Sep 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina BottoniGelsomina Fico
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Sep 6, 2020·Antioxidants·Vidmantas BendokasJulius Liobikas
Aug 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Seyyed Mojtaba MousaviNelson Pynadathu Rumjit

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