PMID: 8613621Mar 15, 1996Paper

Amelioration of severity of myocardial injury by a nitric oxide donor in rabbits fed a cholesterol-rich diet

Journal of the American College of Cardiology
S HoshidaM Tada

Abstract

This study compared the effect of a nitric oxide donor on limiting the size of infarct resulting from myocardial ischemia-reperfusion between atherosclerotic and nonatherosclerotic models. Endothelial-derived relaxation in coronary arteries affected by ischemia is substantially impaired after reperfusion, and this impairment may exacerbate the myocardial ischemia-reperfusion injury. In animals with experimental atherosclerosis, release of endothelial-derived relaxing factor is also decreased, and the propagation of myocardial infarction could be exacerbated. We examined the extent of myocardial injury induced by ischemia (30 min) and reperfusion (48 hr) in rabbits fed a cholesterol-rich (1%) or normal diet for 10 weeks. We also evaluated the effect of a nitric oxide donor (S-nitroso-N-acetylpenicillamine [SNAP], a nitric oxide precursor (L-arginine) or a degradation product of SNAP (N-acetylpenicillamine) on infarct size in these models. Severity of myocardial injury was significantly exacerbated in cholesterol-fed rabbits (75.2 +/- 4.4% [mean +/- SEM]) compared with that in non-cholesterol-fed rabbits (53.2 +/- 5.2%). This exacerbation was prevented by treatment with SNAP (50.2 +/- 6.4%) but not with L-arginine (70.5 +/- 6.0%)...Continue Reading

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Citations

Apr 27, 2000·Atherosclerosis·D T KremastinosE K Iliodromitis
Dec 19, 2012·Antioxidants & Redox Signaling·Dler Faieeq Darweesh MahmoodMustapha Rouis
Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kyle S McCommisChristopher P Baines
Aug 1, 2015·British Journal of Pharmacology·S M R CosynsR A Lefebvre
Jan 5, 2001·Expert Opinion on Investigational Drugs·A LermanJ L Velianou
Apr 1, 2000·Clinical and Experimental Hypertension : CHE·O JungW Linz
Oct 13, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Alaaeldin I SalehMohamed Z Gad
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Aug 13, 1998·Journal of Cardiovascular Pharmacology·Z SzilvássyG T Elliott
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S HoshidaM Hori

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