Amelioration of the cardiovascular manifestations of the yellow scorpion Leiurus quinquestriatus envenomation in rats by red grape seeds proanthocyanidins

Toxicon : Official Journal of the International Society on Toxinology
Abir T El-AlfyFarida Kader

Abstract

The study attempts to determine the involvement of oxidative stress in cardiovascular manifestations during Leiurus quinquestriatus quinquestriatus (LQQ) scorpion envenomation and to examine the possible protective role of red grape seed proanthocyanidins (GSP) against such effects. Lethality studies conducted in mice demonstrated a significant (p<0.01) protection of GSP against venom lethality. Pretreatment with GSP (200 mg kg(-1), p.o., 10 days) prior to venom injection (350 microg kg(-1), s.c.) resulted in a significant decrease in percent mortality as well as in significant prolongation of the animal's survival time (p<0.01). Monitoring the cardiovascular effects elicited by venom injection in anesthetized rats revealed a marked protection of GSP against the increase in mean arterial blood pressure evoked by LQQ venom. Moreover, pretreatment with GSP reduced the characteristic signs of conduction defects, myocardial ischemia, and infarction observed by venom injection. Biochemical analyses showed that scorpion envenomation caused significant (p<0.001) elevation in serum lactate dehydrogenase as well as creatine kinase-MB activities. Such elevation was ameliorated by GSP (p<0.001). Oxidative stress parameters revealed that s...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·R G Grange
Oct 1, 1971·Toxicon : Official Journal of the International Society on Toxinology·R W CarlsonF E Russell
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jul 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·M Ismail
Jul 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·F BucaretchiF S Tourinho
Jun 18, 1999·Journal of Molecular and Cellular Cardiology·M SatoD K Das
Sep 22, 1999·European Journal of Biochemistry·L D PossaniJ Tytgat
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·A J FataniE G Rowan
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Palmira Cupo, Sylvia Evelyn Hering
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Nuhan Purali
Mar 12, 2003·Mutation Research·Debasis BagchiJoe A Vinson
Apr 28, 2004·Toxicon : Official Journal of the International Society on Toxinology·Christiane DevauxHervé Rochat
May 26, 2004·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Aviva Weisel-Eichler, Frederic Libersat
Aug 18, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Marcus V AndradeJosé R Cunha-Melo
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Akira TakaharaKeitaro Hashimoto
May 24, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E DoussetR Guieu
May 25, 2005·Brain Research·Hong Im KimJin-Ho Song
Jul 6, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Flávio VasconcelosEliane Candiani Arantes
Jul 11, 2006·International Journal of Cardiology·K KarthikeyanS Niranjali Devaraj
Aug 29, 2006·Toxicon : Official Journal of the International Society on Toxinology·Graham M NicholsonKevin W Broady

❮ Previous
Next ❯

Citations

Aug 5, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chan-Min LiuJian-Mei Sun
Nov 2, 2013·Pakistan Journal of Biological Sciences : PJBS·Abhijit DeyJitendra Nath De
Jul 5, 2015·Toxicon : Official Journal of the International Society on Toxinology·F Costal-OliveiraC Chávez-Olórtegui
May 19, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Hassan ArganiHadi Ilghami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.