Amelioration of titanium dioxide nanoparticles-induced liver injury in mice: possible role of some antioxidants

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Samy A Abdel AzimMai O Kadry

Abstract

This study investigates the efficacy of idebenone, carnosine and vitamin E in ameliorating some of the biochemical indices induced in the liver of titanium dioxide nanoparticles (TiO2 NPs) intoxicated mice. Nano-anatase TiO2 (21 nm) was administered (150 mg/kg/day) for 2 weeks followed by the aforementioned antioxidants either alone or in combination for 1 month. TiO2 NPs significantly increased serum liver function enzyme activities, liver coefficient and malondialdehyde levels in hepatic tissue. They also suppressed hepatic glutathione level and triggered an inflammatory response via the activation of macrophages and the enhancement of tumor necrosis factor-α and interleukin-6 levels. Moreover, the mRNA expression of nuclear factor-erythroid-2-related factor 2, nuclear factor kappa B and Bax was up-regulated whereas that of Bcl-2 was down-regulated following TiO2 NPs. Additionally, these NPs effectively activated caspase-3 and caused liver DNA damage. Oral administration of idebenone (200mg/kg), carnosine (200mg/kg) and vitamin E (100mg/kg) alleviated the hazards of TiO2 NPs with the combination regimen showing a relatively higher effect. The histopathological examination reinforced these findings. In conclusion, oxidative st...Continue Reading

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Citations

Oct 25, 2016·Environmental Toxicology and Pharmacology·Bin SongLongQuan Shao
May 25, 2018·Human & Experimental Toxicology·X DaiJ Yi
Sep 27, 2018·International Journal of Veterinary Science and Medicine·Khaled M A Hassanein, Yasmin O El-Amir
Feb 6, 2020·International Journal of Molecular Sciences·Piergiorgio La RosaFiorella Piemonte
Jun 3, 2018·Journal of Nanobiotechnology·Hans Christian WinklerHanspeter Naegeli
Jan 10, 2021·Environmental Science and Pollution Research International·Mohammad Rafiq WaniGhulam Shadab
Mar 17, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Erol AkpinarBusra Dincer
May 13, 2021·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Flavourings (FAF)Matthew Wright

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