Ameliorative effect of allopurinol on vascular complications of insulin resistance

Journal of Diabetes Research
Hany M El-BassossyAbdulrahman M Alahdal

Abstract

The aim of the current study was to evaluate the possible protective effect of allopurinol (Allo) on experimentally induced insulin resistance (IR) and vascular complications. Rats were divided into four groups: control, IR, allopurinol-treated IR (IR-Allo), and allopurinol-treated control (Allo). IR was induced by adding fructose and high fat, high salt diet for 12 weeks. The results showed that Allo has alleviated the increased level of TNF-α and the systolic, diastolic, mean, and notch pressure observed in IR with no change in pulse pressure. In addition, Allo decreased the heart rate in the treated group compared to IR rats. On the other hand, it has no effect on increased levels of insulin, glucose, fructosamine, or body weight gain compared to IR group, while it increased significantly the insulin level and body weight without hyperglycemia in the control group. Moreover, Allo treatment ameliorated increased level of 4HNE, Ang II, and Ang R1. In conclusion, the results of the current study show that Allo has a protective effect on vascular complications of IR which may be attributed to the effect of Allo on decreasing the TNF-α, 4HNE, Ang II, and Ang R1 as well as increasing the level of insulin secretion.

References

May 1, 1992·Archives of Biochemistry and Biophysics·P C PanusB A Freeman
Nov 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H P FriedlP A Ward
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Feb 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M L ShermanD W Kufe
Apr 1, 1995·Southern Medical Journal·S TanD A Parks
Nov 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K R FeingoldC Grunfeld
Sep 26, 1997·The Journal of Clinical Investigation·E FerranniniG Mingrone
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·P M HassounJ J Lanzillo
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Oct 21, 2000·Journal of Molecular and Cellular Cardiology·J W de JongC Ceconi
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
Dec 1, 2001·Transplantation·D A NealG J Alexander
Dec 19, 2001·Journal of Cardiothoracic and Vascular Anesthesia·P H McNultyC E Chambers
Jul 10, 2002·Circulation·Colin A J FarquharsonAllan D Struthers
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Timo E Strandberg, Kaisu Pitkala
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Matthias B SchulzeFrank B Hu
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Apr 21, 2005·Kidney International·Uday M KhoslaRichard J Johnson
Oct 20, 2005·American Journal of Physiology. Renal Physiology·Takahiko NakagawaRichard J Johnson
Jan 6, 2006·The Journal of Clinical Investigation·Jaap G Neels, Jerrold M Olefsky
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Sep 14, 2007·Clinical Pharmacology and Therapeutics·J A BatsisF Lopez-Jimenez
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandra ShapiroPhilip J Scarpace
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Xue GaoCuihua Zhang
Aug 22, 2009·American Journal of Nephrology·Carlos A RoncalRichard J Johnson
Jul 30, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Hany M El-BassossyMona F Mahmoud
Nov 24, 2012·Current Pharmaceutical Design·Davide GrassiClaudio Ferri

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
glycosylation

Software Mentioned

ImageJ
LabChart
Prism
Allo

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.