Ameliorative effect of carvacrol against propiconazole-induced neurobehavioral toxicity in rats

Neurotoxicology
Peter A NoshyEman I Hassanen

Abstract

Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of acetylcholinesterase enzyme in neural tissue was also observed in PCZ-exposed rats. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, co-administration of CAR ameliorate...Continue Reading

Citations

May 20, 2020·Journal of Histotechnology·Abd El-Fattah M El-ShershabyAbeer A Ahmed
Dec 15, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lícia T S PinaMairim R Serafini
Oct 29, 2020·The Chinese Journal of Physiology·Victor Manuel Munoz-PerezAndrés Salas-Casas
Feb 23, 2021·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Luc Mohimont
Apr 11, 2021·Neurotoxicology and Teratology·Peter A Noshy, Rehab A Azouz
Aug 16, 2021·Journal of Biochemical and Molecular Toxicology·Ashraf M MorganAhmed M Hussien
May 11, 2021·CNS & Neurological Disorders Drug Targets·Mohammad Yassin ZamanianGholamreza Bazmandegan

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