Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats.

Environmental Science and Pollution Research International
Islam M SaadeldinAyman Abdel-Aziz Swelum

Abstract

Phthalates (such as DEHP) and bisphenol A (BPA) are widely used chemicals in plastics manufacturing and exert public health concerns as endocrine disrupters. This study was designed to investigate the deleterious effect of DEHP and BPA on endocrine profile of pregnant female rats and the combined treatment with ginseng extract (Panax ginseng). Seventy-two pregnant rats were divided into six groups (control, ginseng, DEHP, BPA, Gin + DEHP, and Gin + BPA), 12 females per each group. The drugs were supplemented from pregnancy day 0 until day 20. Determination of serum sex hormones (testosterone, progesterone, and estradiol) were determined on days 4, 10, and 20 of pregnancy. mRNA transcripts of STAR, HSD17B3, CYP17, AKT1, and PTEN were relatively quantified against ACTB in the ovary and placenta of days 10 and 20 pregnant females by relative quantitative polymerase-chain reaction (RQ-PCR). DEHP and BPA significantly decreased the endocrine profile of testosterone, progesterone, and estradiol of days 10 and 20 of pregnant females. Combined administration of these chemicals along with ginseng extracts has returned the hormones to normal levels when compared with the control group. The ovarian and placental CYP17 and HSD17B3 mRNA tra...Continue Reading

References

Mar 1, 1981·Biology of Reproduction·G Gibori, R Sridaran
Jun 1, 1995·Environmental Health Perspectives·J A BrotonsN Olea
Jul 1, 1997·Biochemical Pharmacology·C N Gillis
Oct 3, 1998·The Journal of Biological Chemistry·C B KallenJ F Strauss
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Nov 24, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·V D ShultzK W Gaido
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 6, 2002·Environmental Health Perspectives·Gilbert SchönfelderIbrahim Chahoud
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Norman J BarlowPaul M D Foster
Apr 26, 2005·FEBS Letters·Pascal FromentJoëlle Dupont
Jun 10, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Leon Earl GrayJoseph Ostby
Jan 16, 2007·PLoS Genetics·Martha SusiarjoPatricia A Hunt
Jan 24, 2009·Biology of Reproduction·Ailene MuhlhauserPatricia A Hunt
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Oct 13, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Arul Murugan ManiD Claire Wathes
Nov 17, 2009·Trends in Endocrinology and Metabolism : TEM·Pradeep ReddyKui Liu
Feb 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donald G StumpSteven G Hentges
Jan 15, 2011·Environmental Health Perspectives·Tracey J WoodruffJackie M Schwartz
Jun 26, 2013·Annales d'endocrinologie·Patrick FenichelFrançoise Brucker-Davis
Jun 5, 2014·Environmental Health Perspectives·Jackye PeretzJodi A Flaws
Oct 15, 2014·Journal of Molecular Endocrinology·Annu MakkerAbbas Ali Mahdi
Feb 24, 2015·Frontiers in Endocrinology·Patrick R Hannon, Jodi A Flaws
Jul 5, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Naglaa A BayomyEman Z Abdelaziz
Oct 20, 2018·Journal of Ginseng Research·Sang Yun HanJae Youl Cho

❮ Previous
Next ❯

Citations

Jan 23, 2019·Environmental Science and Pollution Research International·Maryam ShiraniMohammad Amin Dehghani
Jul 30, 2020·Biomolecules·Shehreen AmjadMyung-Geol Pang
Aug 9, 2019·Environmental Science and Pollution Research International·Mohamed M A HusseinIslam M Saadeldin
Jun 4, 2020·Environmental Science and Pollution Research International·Chao HanWanyu Shi
Jul 2, 2019·Critical Reviews in Toxicology·Manoj Sonavane, Natalie R Gassman
Jan 25, 2020·Environmental Science and Pollution Research International·Jian-Qing WangFang-Biao Tao
Jan 8, 2021·Environmental Science and Pollution Research International·Bin-Bin ZhuDe-Xiang Xu
Jul 2, 2020·Molecular and Cellular Endocrinology·Natalie A DeWittAmanda N Kallen
May 21, 2021·Reproductive Toxicology·Genoa R WarnerJones B Graceli
Oct 2, 2021·Environmental Science and Pollution Research International·Lian KangShengde Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.