Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats

Life Sciences
Irfan CinarZekai Halici

Abstract

Sepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs. Cecal ligation and puncture (CLP) induced sepsis model was induced in rats. Effects of GOS on oxidative stress, histopathology, nuclear factor kappa B (NF-κB), IL-6 positivity and NLRP3, HMGβ1, TNF-α, NF-κB, IL-1β mRNA expression levels were evaluated in lung tissues of the septic rats. GOS 20 (20 mg/kg) administration to septic rats decreased oxidative stress and supported antioxidant system in lungs. GOS administration also decreased the tissue NF-κB and IL-6 immunopositivity, which is high in septic rats; and decreased the sepsis-induced lung injury. HMGβ1, NLRP3, NF-κB, IL-1β, and TNF-α mRNA expression significantly increased in the CLP group. Both doses of GOS significantly reduced these mRNA expression as compared ...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 1, 1984·Critical Care Medicine·K TakedaI Yoshiya
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
May 29, 1998·The Journal of Trauma·C N ComptonS A Dulchavsky
Jul 10, 1999·Science·H WangK J Tracey
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 22, 2002·Intensive Care Medicine·Corinne AlbertiRoger Le Gall
Dec 7, 2002·The International Journal of Biochemistry & Cell Biology·Alfred AyalaChun-Shiang Chung
Mar 9, 2005·Critical Care Medicine·Jonas Sundén-CullbergCarl Johan Treutiger
Nov 4, 2005·American Journal of Physiology. Cell Physiology·Jong Sung ParkEdward Abraham
Dec 24, 2005·Shock·William J HubbardIrshad H Chaudry
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ivan Rubio-GayossoBrian R Duling
Jun 13, 2006·The International Journal of Biochemistry & Cell Biology·Vinay Tergaonkar
Sep 27, 2006·Handbook of Experimental Pharmacology·K Ley, J Reutershan
Mar 11, 2008·Cell·Martin KellerHans-Dietmar Beer
Dec 25, 2008·Phytotherapy Research : PTR·Sripal Reddy MadaDevarakonda Rama Krishna
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Aug 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kingshuk Roy ChoudhuryJoseph G Rajendran
Mar 30, 2010·Cytokine·Wenchang HuangLei Li
Aug 12, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qing-Wu YangJing-Zhou Wang
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tuanzhu HaChuanfu Li
Mar 31, 2012·American Journal of Respiratory and Critical Care Medicine·Tamás DolinayAugustine M K Choi
Jul 5, 2012·American Journal of Physiology. Renal Physiology·May M RabadiBrian B Ratliff
Mar 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary W NaceAllan Tsung

❮ Previous
Next ❯

Citations

Aug 30, 2019·The Journal of Trauma and Acute Care Surgery·HongLiang ZhaoLiangMing Liu
Jun 17, 2020·Drug Development Research·Qiannan JiangHong Jiang
Aug 18, 2020·Inflammation·Ugur KostakogluHuseyin Avni Uydu
Nov 13, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Demet CelebiZafer Bayraktutan
Feb 5, 2021·The Journal of International Medical Research·Qi GaoDonglian Liu
Mar 17, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Erol AkpinarBusra Dincer
Dec 22, 2021·The Journal of Obstetrics and Gynaecology Research·Busra DincerErdem Toktay
Jul 24, 2020·Anti-cancer Agents in Medicinal Chemistry·Irfan Cinar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here