Ameliorative Effect of Grape Seed Proanthocyanidin Extract on Cadmium-Induced Meiosis Inhibition During Oogenesis in Chicken Embryos

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Fuyin HouYuling Mi

Abstract

Cadmium (Cd) is an environmental endocrine disruptor that has toxic effects on the female reproductive system. Here the ameliorative effect of grape seed proanthocyanidin extract (GSPE) on Cd-induced meiosis inhibition during oogenesis was explored. As compared with controls, chicken embryos exposed to Cd (3 µg/egg) displayed a changed oocyte morphology, decreased number of meiotic germ cells, and decreased expression of the meiotic marker protein γH2AX. Real time RT-PCR also revealed a significant down-regulation in the mRNA expressions of various meiosis-specific markers (Stra8, Spo11, Scp3, and Dmc1) together with those of Raldh2, a retinoic acid (RA) synthetase, and of the receptors (RARα and RARβ). In addition, exposure to Cd increased the production of H2 O2 and malondialdehyde in the ovaries and caused a corresponding reduction in glutathione and superoxide dismutase. Simultaneous supplementation of GSPE (150 µg/egg) markedly alleviated the aforementioned Cd-induced embryotoxic effects by upregulating meiosis-related proteins and gene expressions and restoring the antioxidative level. Collectively, the findings provided novel insights into the underlying mechanism of Cd-induced meiosis inhibition and indicated that GSPE ...Continue Reading

References

Nov 1, 2000·Chemosphere·L A LieneschJ A Bantle
Jul 29, 2004·DNA Repair·Oscar Fernandez-CapetilloAndré Nussenzweig
Jan 15, 2008·Trends in Genetics : TIG·Patricia A Hunt, Terry J Hassold
Feb 16, 2008·Toxicology and Applied Pharmacology·Zhiwei LiuZahir A Shaikh
Mar 28, 2008·Reproductive Toxicology·Jennifer Thompson, John Bannigan
Feb 25, 2009·Toxicology and Applied Pharmacology·Jie LiuMaria B Kadiiska
Apr 4, 2009·Toxicology and Applied Pharmacology·Gunnar F Nordberg
Apr 18, 2009·Toxicology and Applied Pharmacology·Frank Thévenod
Dec 23, 2009·Toxicology and Applied Pharmacology·Jennifer ThompsonJohn Bannigan
Feb 16, 2010·Toxicology and Applied Pharmacology·Xinyuan YuZahir A Shaikh
Jul 31, 2010·Human Reproduction·R Le BouffantG Livera
Feb 22, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tongliang BuCaiqiao Zhang
Aug 25, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Zelieann R CraigJodi A Flaws
May 1, 2012·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Małgorzata DżuganJerzy W Niedziółka
Nov 14, 2012·General and Comparative Endocrinology·Sumana Das, Dilip Mukherjee
Sep 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yuling MiCaiqiao Zhang
May 29, 2014·Gastroenterology Research and Practice·Dae Young CheungJae Kwang Kim
Aug 28, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pan GuoZhou Zhou
Oct 8, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Qichun SongXiaoqian Dang
Oct 18, 2014·Reproduction in Domestic Animals = Zuchthygiene·M del C DíazC G Barbeito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.