Ameliorative effect of resveratrol on testicular oxidative stress, spermatological parameters and DNA damage in glyphosate-based herbicide-exposed rats

Andrologia
F AvdatekHasan Huseyin Demirel

Abstract

In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20 mg kg-1 daily-1 RES, group III received normal feed containing 375 mg kg-1 daily-1 GLF, and group IV received normal feed containing 375 mg kg-1 daily-1 GLF+20 mg kg-1 daily-1 RES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats. On the other hand, abnormal sperm rate, malondialdehyde level, and DNA damage were detected to be high in the group treated with GLF. The findings indicate that RES protects spermatological parameters and DNA damage, decreases GLF-induced lipid peroxidation, improves the antioxidant defence mechanism and regenerates tissue damage in the testis of rats.

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Citations

Oct 6, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Amany Mohamed ShalabyDina Fouad El Shaer
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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